CT评估部分液体通气对犬吸入性肺损伤作用的实验研究  

Computer tomographic assessment of partial liquid ventilation in dogs with inhalation injury

作　　者：汪丽娅[1] 郭光华[2] 范锟铻 龚洪翰[1] 肖香佐[1] 李国辉[2] 周莉[2] 傅丽晖 

机构地区：[1]江西医学院第一附属医院影像科,南昌330006 [2]江西医学院第一附属医院烧伤中心,南昌330006 [3]广东省深圳市第二人民医院烧伤整形科

出　　处：《中华放射学杂志》2004年第3期310-313,共4页Chinese Journal of Radiology

基　　金：国家自然科学基金资助项目;江西省主要学科跨世纪学术和技术带头人培养计划 (3 9760 0 73 )

摘　　要：目的　通过分析比较犬吸入性肺部损伤的CT表现和病理结果 ,为探讨部分液体通气(PLV)治疗吸入性损伤的机理提供实验依据。方法　选用 14条杂种犬 ,采用蒸气吸入造成急性呼吸道损伤后将其分为单纯高频通气对照组与氟碳 (PFC)部分液体通气 +高频通气治疗组。分别对治疗组和对照组犬进行肺部CT扫描 ,同时观察对照组与治疗组的组织病理学变化 ,并将CT和病理结果进行分析、比较。结果　CT表现为斑片状、团絮样模糊的渗出性病灶者 6条犬 ,散在性、点片状渗出灶者 2条犬 ,淡薄、斑片状的磨玻璃样改变者 2条犬 ,部分肺实变者 4条犬 ;PFC在吸入性损伤犬的肺部呈斑块状者 5条犬 ,团絮状者 2条犬 ,弥散者 1条犬 ,其分布也以肺的背侧为主 ,与病理结果一致。结论　PFC液体通气在犬的吸入性肺损伤的分布主要集中在肺的重力依赖区 ,而气体更多地分布在肺的非依赖区 ,与肺的损伤部位一致 ,利于吸入性损伤的治疗。Objective To analyze CT and pathologic findings of lung in dogs with inhalation injury,and to provide reliable basis to explore the mechanism of partial liquid ventilation (PLV) treatment on inhalation injury.Methods Respiratory tract injury models in 14 dogs were made by steam inhalation and they were divided into 2 groups.The control group was treated by high frequency ventilation (HFV) and the treatment group was treated by partial liquid with perfluorocarbon plus HFV.CT scan of the lung in dogs with inhalation injury was performed before and after perfluorocarbon (PFC) PLV,and then the histopathologic pieces with isolation lung were obtained.Analysis and comparison of the results among them was conducted.Results After steam inhalation injury,CT appeared as exudation with patchy and mass in 6 dogs,cotton-wool spots in 2 dogs,ground-glass opacity in 2 dogs,and consolidation in 4 dogs.CT appeared as mass in 5 dogs with inhalation injury of perfluorocarbon-filled lungs during partial liquid ventilation,patchy in 2 dogs,and homogeneous in 1 dog.The distribution of perfluorocarbon was in the posterior region of lung.The CT findings were in accordance with those in histopathology.Conclusion Perfluorocarbon is distributed predominantly in the dependent regions of the lung and the distribution of perfluorocarbon is gravity dependent.It is benefit for the inhalation injury.

关 键 词：CT评估 液体通气 吸人性肺损伤 实验研究 氟化合物 动物实验 

分 类 号：R816.4[医药卫生—放射医学]