甲亢患者骨密度、骨代谢指标及维生素D受体的变化  

Changes of bone mineral density, bone metabolism indices and Vitamin D receptor content in patients with hyperthyroidism

作　　者：梁晓萍[1] 文锦丽[1] 周文英[1] 钟紫茹[1] 周雅莹[1] 

机构地区：[1]深圳市人民医院临床医学研究中心,518020

出　　处：《中华内分泌代谢杂志》2004年第2期127-128,共2页Chinese Journal of Endocrinology and Metabolism

摘　　要：本研究发现甲状腺功能亢进症 (甲亢 )患者腰椎、股骨颈、Ward三角和大转子区骨密度降低 ,血清钙、血清磷、血清碱性磷酸酶及血清骨钙素升高 ,血淋巴细胞内维生素D受体 (VDR)含量降低。FT3与FT4与骨密度呈负相关。提示甲亢导致高转换型骨丢失 ,它可引起骨密度降低 ,骨代谢指标及VDR含量异常。Bone mineral density (BMD) of lumbar spines, femoral neck, Ward′s triangle and greater trochanter was lowered, serum calcium, phosphate, alkaline phosphatase and bone Gla-protein levels were raised, and vitamin D receptor (VDR) contents in lymphocyte was lowered in hyperthyroid patients. Both FT 3 and FT 4 were negatively correlated with BMD, suggesting that hyperthyroidism results in high-turnover type of bone loss which causes the abnormalities of bone metabolic indices and VDR content.

关 键 词：骨密度 骨代谢指标 维生素D受体 甲状腺功能亢进症 

分 类 号：R581.1[医药卫生—内分泌]