新的氧输送渠道在防治烧伤休克及减轻缺氧性损伤中的临床应用  

A new method of oxygen delivery to preventing and relieving the anoxia injury-An experimental study and clinical application of hyperoxygen compound sodium chloride solution in treatment of burn shock

作　　者：孙永华[1] 张普柱[1] 胡骁骅[1] 陈忠[1] 程安源[1] 钟穗航 

机构地区：[1]北京积水潭医院烧伤科,100035 [2]广州红十字会医院烧伤科

出　　处：《中华医学杂志》2004年第1期18-21,共4页National Medical Journal of China

基　　金：国家重点基础研究发展规划基金资助项目(G19990 5 42 0 2 ) ;北京市优秀人才培养专项经费资助项目 (D类 ;2 0 0 2年 )

摘　　要：目的　探讨高氧复方氯化钠溶液 (HCSCS)对烧伤休克的防治作用和预后。方法　 (1 )选择 2 0 0 1年 1月～ 2 0 0 3年 1月北京积水潭医院烧伤科收治的烧伤面积 5 0 %～ 6 9%的烧伤病人 ,随机分为 2组 ,分别是治疗组补充高氧复方氯化钠溶液、对照组补充复方氯化钠溶液 ,观察休克期度过平稳与否、经皮氧分压、血红蛋白 (Hb)、血球压积 (Hct)以及其并发症等 ,判断高氧液的疗效。 (2 )选择 2 0 0 2年～ 2 0 0 3年烧伤面积 >70 %病人 1 6例观察其氧分压 (PaO2 )、并发症、血色素 (Hb)、血球压积(Hct)、血乳酸 (Lactate)以及总补液量和尿量。结果　临床观察中 ,(1 )治疗组较对照组休克期度过平稳、并发症少 ,4 8h输液总量少 ,血氧分压和经皮氧分压明显高于对照组 ,血氧饱和度无差异性。 (2 )烧伤面积 >70 %病人血氧分压维持水平较高 ,血乳酸基本在正常范围内 ,仅 2例出现并发症 ,1例死亡。Objective To evaluate the clinic effects and prognosis of hyperoxygen compound sodium chloride solution (HCSCS) in treatment of burn shock. Methods (1) Severe burned patients with 50%～69% TBSA were enrolled and randomly divided into 2 groups,treated by HCSCS and CSCS respectively. Indices such as PaO 2, Hb, Hct and complication were observed. (2) Severe burned patients with more than 70% TBSA were enrolled and indices above and lactate were investigated as well. Results (1) The cases treated with HCSCS showed relatively stabilization during shock stage, little complication, less liquor volume and remarkable higher oxygen pressure. (2) Severe burned patients with more than 70% TBSA had high level of PaO 2 and normal lactate and less complication. Conclusion The early application of HCSCS is a relatively effective method in treatment of burn shock and favourable prognosis.

关 键 词：氧输送渠道 烧伤 休克 缺氧性损伤 预后 血氧分压 

分 类 号：R644[医药卫生—外科学]