百白破联合疫苗基础免疫后不同时间的抗体水平研究  

Study on Antibody Titer in Different Time Intervals after Immunized by DTwP Vaccine

作　　者：侯启明[1] 马宵[1] 张庶民[1] 梁雅文[1] 赵建荣[1] 张路民[1] 吕慧贤[1] 田霖[1] 顾磊[1] 雷殿良[1] 

机构地区：[1]中国药品生物制品检定所,北京100050

出　　处：《中国计划免疫》2004年第2期81-83,共3页Chinese Journal of Vaccines and Immunization

摘　　要：为了解全细胞百白破联合疫苗 (DTwP)基础免疫后抗体持续时间 ,对DTwP免疫 3针后间隔 1个月和 2个月的百日咳、白喉、破伤风抗体水平的变化进行了初步研究 ,结果表明 :免疫后 2个月 ,白喉、破伤风抗体滴度 ,与免疫前相比 ,差异均有显著的统计学意义 ,并且仍然远 >0 0 1HAU的保护水平。百日咳疫苗免疫后 2个月 ,其抗体滴度仅为免疫后 1个月抗体滴度的 2 5 %左右 ,免疫后 1个月和 2个月抗体滴度间差异有非常显著的统计学意义。The study on persistence of antibody level of DTwP vaccine was carried out in order to investigate change of antibody titer 1 and 2 months after immunization. 156 healthy infants of 3-6 months old were selected.Three injections of DTwP vaccine were given with time interval of 1 month.The first injection was at 3 months old.Blood samples were collected before immunization,1 and 2 months after immunization.The results showed that antibody titers of both diphtheria and tetanus toxoid exceeded far more than 0.01 HAU protective level after immunized 2 months.The agglutinin antibody titer of pertussis declined by 75% after immunized 2 months,the difference had statistical significance.

关 键 词：基础免疫 抗体滴度 全细胞百白破联合疫苗 测定 破伤风类毒素 白喉类毒素 

分 类 号：R186[医药卫生—流行病学]