超声对兔关节软骨损伤的修复作用  

Effect of ultrasound in repair of rabbit articular cartilage injury

作　　者：贾小林[1] 陈文直[1] 司海鹏[2] 王智彪[1] 

机构地区：[1]重庆医科大学医学超声工程研究所 [2]重庆医科大学病理教研室,400016

出　　处：《中华创伤杂志》2004年第2期97-99,共3页Chinese Journal of Trauma

基　　金：国家"九五"重点科技攻关项目 (96-90 5 -0 2 -0 1);国家自然科学基金重点课题资助项目 (3 963 0 3 3 40 )

摘　　要：目的　探讨低强度脉冲超声对兔膝关节软骨损伤的修复作用。　方法　于 33只新西兰兔股骨髁间窝软骨面处钻孔 ,伤后左后肢膝关节缺损处以低强度脉冲超声辐照 ,右后肢予以假照作为对照。分别于伤后 2 ,4和 8周处死 ,做大体及病理组织学观察。　结果　超声辐照组修复组织成熟度较对照组高 ,修复时间明显提前 ,第 8周辐照组修复组织已接近正常透明软骨组织 ;对照组修复组织较为幼稚 ,接近纤维软骨组织。　结论　低强度脉冲超声能促进兔关节软骨损伤的修复。Objective To observe the effect of low intensity pulsed ultrasound (LIPU) in repair of the articular cartilage injury in rabbits. Methods Osteochondral defects in the cartilage surfaces of femoral intercondylar fossae were made in 33 healthy adult New Zealand White rabbits, of which the knee lesions of the left hind legs were treated with LIPU (LIPU group) while that of the right ones used as control group. All animals in two groups were sacrificed respectively at the 2nd, 4th and 8th weeks postoperatively for gross appearance observation and histological examination. Results The ultrasound-treated tissues became more mature with in advance repair or regeneration. The repaired tissues in the LIPU group were near to normal hyaline cartilage tissues at the 8th week postoperatively, while the repaired tissues in the control group were weak, near to fibrocartilaginous tissues. Conclusion LIPU can promote repair of articular cartilage injury in rabbits.

关 键 词：关节软骨损伤 低强度脉冲超声 组织修复作用 矫形外科 骨组织 

分 类 号：R684[医药卫生—骨科学]