丽珠肠乐治疗溃疡性结肠炎的临床疗效及病理变化的研究  

Studies on the microecological changes and the prevention and therapy by Bifidobacterium of ulcerative colitis

作　　者：杨春辉[1] 杨景云[2] 刘德欣[1] 宋彬彬[1] 

机构地区：[1]牡丹江医学院红旗医院消化内科,黑龙江牡丹江157011 [2]佳木斯大学医学院微生态研究室,黑龙江佳木斯154002

出　　处：《中国微生态学杂志》2004年第2期98-99,共2页Chinese Journal of Microecology

摘　　要：目的 :探讨溃疡性结肠炎的微生态学改变及双歧杆菌对溃疡性结肠炎的预防和治疗作用。方法 :随机选取溃疡性结肠炎的患者 6 0人 ,分成二组。治疗组 :口服丽珠肠乐胶囊 ;对照组 :口服氟哌酸胶囊 ,柳氮磺胺吡啶栓直肠给药。疗程一个月。结果 :溃疡性结肠炎的肠道内细菌数量双歧杆菌、乳杆菌显著下降 (P <0 0 1) ,肠球菌显著增加 (P <0 0 1)。经丽珠肠乐治疗后 ,肠道内主要细菌的数量恢复正常 ,与对照组相比差异有显著性 (P <0 0 1) ;肠道黏膜病理及组织学改变基本恢复正常 ;临床症状改善上治疗组疗效高于对照组 (P <0 0 1)。结论 :双歧杆菌活菌制剂治疗溃疡性结肠炎效果显著 ,值得临床推广使用。Objective:To study the microecological changes and the prevention and therapy by Bifido bacterium (BF) of ulcerative colitis.Methods:60 cases were randomly divided two grous.Therapeutic group was given by oral BF.Control norfloxacin and suppository Sulfasalazine.Results:The quantities of main bacteria in Ulcerative colitis such as Bifidobacterium and Lactobacillas decreased(P<0.01),while Enterococcus increased comparing with the control group(P<0.01).In Bifido bacterium the quantities of the intestines main bacteria such as Bifido bacterium and Lactobaccillus increased (P<0.01),while Enterococcus decreased with the control(P<0.01).Pathologic and Ultrastructral observations showed the structure of intestines mucosa were restored to normal.Clinical symptom was significantly improved in therapeutic group compared with control group(P<0.01).Conclusion:It was very good that effect of therapy of Ulcerative colitis with BF.

关 键 词：丽珠肠乐 治疗 溃疡性结肠炎 临床疗效 病理变化 双歧杆菌 微生态调节剂 

分 类 号：R378.992[医药卫生—病原生物学] R574.62[医药卫生—基础医学]