表皮生长因子影响鼠小肠增量杨氏模量的研究  

THE INCREMENTAL YOUNG'S MODULI IN THE RAT SMALL INTESTINE CAUSED BY EPIDERMAL GROWTH FACTOR

作　　者：廖东华[1] 高松[1] 曾衍钧[1] 刘有军[1] 杨坚[2] 赵静波 L.Vinter-Jensen H.Gregersen 

机构地区：[1]北京工业大学生物力学与医学信息研究所,北京100022 [2]北京工业大学生物力学 [3]丹麦Aalborg大学生物力学实验室 [4]丹麦Aarhus大学医院临床实验研究所

出　　处：《力学学报》2004年第2期171-176,共6页Chinese Journal of Theoretical and Applied Mechanics

基　　金：国家自然科学基金(10072006)~~

摘　　要：研究表皮生长因子(EGF)2,4,7,14d处理后鼠小肠所发生的生物力学重建。通过双轴试验(膨胀与轴向拉伸组合),用最小二乘法计算了近于在体状态下环向、纵向及交叉向增量杨氏模量。各组环向和纵向模量均不相等,即正常状态和EGF处理后的小肠是各向异性的。在EGF处理期间,各向的杨氏模量随时间变化(P<0.05)。在EGF处理的最初7d中,环向模量减小,在处理14d后,又恢复到对照组的水平。增量模量介于17.4kPa与24.2kPa之间。纵向模量的值介于22.9kPa与32.4kPa之间,在处理4d后,比对照值显著增大(P<0.02)。交叉模量的值介于4.7kPa与6.6kPa之间,在最初EGF处理的4d中降低,此后增加并于第7d达到最大值。可以得出结论,肠壁的力学性质呈各向异性且在EGF处理期间会发生重建。Biomechanical remodelling of the rat small intestine after treatment with epidermal growth factor (EGF) subcutaneously for 2 days (n-6),4 days (n=6),7 days (n=6),and 14 days (n=4) was studied.The incremental circumferential,longitudinal and cross moduli close to the in vivo state were computed from bi-axial test data (combined inflation and axial stretching) by a least square method.The moduli in the circumferential direction and the longitudinal direction differed in all groups,i.e.the mechanical properties were anisotropic in both normal and EGF-treated rats.Time-dependent variation existed for the Young's moduli in all directions during EGF treatment (P<0.05).The circumferential modulus decreased during the first 7 days of EGF treatment and it almost remodelled back to that of the control group after 14 days treatment.The incremental modulus in the circumferential direction ranged between 17.4 kPa and 24.2 kPa.The modulus in the longitudinal direction ranged between 22.9kPa and 32.4 kPa.The longitudinal modulus after 4 days EGF treatment was significantly larger than that of control group (P<0.02).The cross modulus decreased during the first 4 days of EGF treatment thereafter it increased to a maximum at 7 days.The values for the cross moduli were between 4.7 kPa and 6.6 kPa.In conclusion,the mechanical properties in the intestinal wall are anisotropic and remodel during treatment with EGF.

关 键 词：表皮生长因子 鼠 小肠 杨氏模量 各向异性 生物物理学 

分 类 号：Q66[生物学—生物物理学]