冠心病患者血清褪黑素的变化  

Serum melatonin in patients with coronary heart disease

作　　者：陈丽华[1] 梁国芬[2] 

机构地区：[1]江汉石油管理局中心医院心内科,湖北潜江433124 [2]华中科技大学附属协和医院心内科华中科技大学同济医学院心血管病研究所

出　　处：《临床心血管病杂志》2004年第5期261-263,共3页Journal of Clinical Cardiology

摘　　要：目的 :研究冠心病患者血清褪黑素 (Melatonin ,MLT)变化 ,了解MLT与冠心病的可能关系 ,观察β 受体阻滞剂对冠心病患者MLT分泌的影响。方法 :用放射免疫分析法测定对照组 2 0例、冠状动脉造影证实冠状动脉高度狭窄的不稳定型心绞痛 (UA)患者 30例 (其中 14例服用 β 受体阻滞剂 )及急性心肌梗死 (AMI)患者33例 (其中 16例服用 β 受体阻滞剂 ) ,清晨 5 :30～ 6 :0 0测血清MLT。分析 3组间血清MLT水平的差异。 结果 :UA组及AMI组血清MLT水平分别为 (2 4 .4 5± 2 0 .80 )、(31.2 2± 2 5 .80 )ng/L ,均明显低于对照组 [(4 7.0 3±2 5 .6 2 )ng/L],差异有统计学意义 (均 P <0 .0 1)。服用与未服用 β 受体阻滞剂的冠心病患者间血清MLT水平差异无统计学意义 (P >0 .0 5 )。结论 :冠心病患者体内血清MLT显著降低 ,βObjective:To explore the changes of serum melatonin in patients with coronary heart disease (CHD) and the effect of beta-blockers on the secretion of melatonin in CHD patients. Method:Three groups of individuals were studied: ①20 controls; ②30 patients with unstable angina (UA) documented severe coronary heart disease by angiography, 14 of them taking beta-blockers daily in therapeutic dosages; ③33 patients with acute myocardial infarction (AMI), 16 of them taking beta-blockers. Serum samples were collected at 5:30～6:00. Am Melatonin was measured radioimmunologically. Result:The levels of serum melatonin in patients with UA and AMI were significantly lower than controls( 24.45± 20.80) ,( 31.22± 25.80)and( 47.03± 25.62)ng/L respectively (all P< 0.01). Melatonin excretion in patients treated with beta-blockers did not differ significantly from those patients not received beta-blockers.Conclusion:The endogenous levels of serum melatonin were significantly decreased in patients with coronary heart disease.

关 键 词：冠状动脉疾病 褪黑素 Β-受体阻滞剂 

分 类 号：R543.3[医药卫生—心血管疾病]