磷酯酰肌醇3激酶在骨骼肌中的调节以及运动对它的影响  

Regulation of phosphatidylinositol 3-kinase in skeletal muscle and the effect of exercise on it

作　　者：高彩暇[1] 刘广圣[2] 

机构地区：[1]华东师范大学体育与健康学院,上海200062 [2]内蒙古大学体育部,内蒙古呼和浩特010021

出　　处：《浙江体育科学》2004年第3期36-39,77,共5页Zhejiang Sport Science

摘　　要：在骨骼肌中磷酯酰肌醇3激酶(PI3K)以异二聚体形态存在。它以及它下游的靶目标和胰岛素受体底物(IRS1,2)一起在胰岛素信号转导通路中发挥重要作用,并参与了胰岛素刺激的葡萄糖转运和 GLUT-4转移;不同强度运动以及运动时间对骨骼肌中PI3K有着不同的作用,这也和胰岛素的调节有关。Phosphatidylinositol 3-kinase(PI3K) exists as an allodimer in skeletal musc1e. PI3K, its downstream target, protein kinase B(PKB/Akt),and insulin receptor play important roles in insulin signaling pathway together, and they are involved in insulin stimulated glucose transport and GLUT-4 transfer. Different intensity of exercise and time of exercise have different effect on PI3K in skeletal muscle, which is also relative with insulin mediation.

关 键 词：P13K 蛋白激酶B(PKB/Akt) 胰岛素信号转导通路 运动 

分 类 号：G804.7[文化科学—运动人体科学]