白蒺藜有效组分对心肌再灌注损伤中一氧化氮和内皮素的影响  

Influence of effective constituents of tribulus terrestris L on nitric oxide and endothelin in the reperfusion injury after myocardial ischemia in rats

作　　者：张恒[1] 顾仁樾[2] 

机构地区：[1]蚌埠医学院附属医院心血管内科,安徽蚌埠233004 [2]上海中医药大学附属龙华医院心内科,上海200032

出　　处：《蚌埠医学院学报》2004年第3期200-202,F004,共4页Journal of Bengbu Medical College

摘　　要：目的 :研究白蒺藜有效组分对心肌缺血再灌注损伤 (IRI)的影响及可能机制。方法 :测定白蒺藜有效组分对在体大鼠心肌缺血再灌注模型的心肌梗死面积、肌酸磷酸激酶 (CK MB)活性水平、血清一氧化氮 (NO)和血浆内皮素 (ET 1 )的影响 ,并观察其超微结构的变化。结果 :与假手术组相比 ,模型组血清NO降低 ,血浆ET 1增高 ,同时其超微结构明显异常 ;而白蒺藜有效组分治疗组可将上述损害减轻并缩小梗死面积。结论 :白蒺藜有效组分可通过改善内皮细胞功能 ,明显减轻心肌IRI。Objective:To study the influence of effective constituents of tribulus terrestris L on myocardial ischemic reperfusion injury(IRI).Methods:The extension of the myocardial areas,CK MB activity and NO content in the serum,the content of ET 1 in the plasma,and the ultrastructure changes in myocardium were observed.Results:As compared with the sham operated group,there were abnormal changes of myocardial ultrastructure in the model group,the level of NO in serum decreased,and the content of ET 1 in plasma increased after IRI.Effective constituents of tribulus terrestris L reversed the indices mentioned above markedly.Conclusions:This study shows that effective constituents of tribulus terrestris L may be regarded as an agent with a marked cardioprotective action against ischemia reperfusion induced myocardial injury by protecting the coronary endothelium in vivo model of the rat heart.

关 键 词：冠状动脉疾病 再灌注损伤 白蒺藜 一氧化氮 内皮素 大鼠 

分 类 号：R541.4[医药卫生—心血管疾病] R619.9[医药卫生—内科学]