糖皮质激素胸腔内给药的时相动力学特征  

Time-concentration-dynamic Characteristics of Glucocorticoid Injected into Pleural Cavity

作　　者：王晓龙[1] 周向东[1] 

机构地区：[1]重庆医科大学附属第二医院呼吸内科,重庆400010

出　　处：《中国药业》2004年第5期28-29,共2页China Pharmaceuticals

摘　　要：目的:探讨结核性胸膜炎患者口服及胸腔内注入糖皮质激素时血清、胸水药物浓度是否有差异。方法:将20例胸膜炎患者随机分为口服组及胸腔内注射给药组。口服组予强的松30mg,顿服,运用反相高效液相色谱法分别测定多个时点血清、胸水标本中强的松浓度;注射给药组仅给药方式不同(地塞米松10mg,胸腔内一次注入),检测方法同口服组。结果:口服组血清、胸水中各时相强的松浓度并无显著性差异,注射组亦如此。结论:结核性胸膜炎患者采用胸腔内注射给药的方式并未显示出药物在胸膜腔内浓聚的特点,故较口服给药并不具备更优越的价值。Objective:To investigate the different drug concentration in patients with tuberculous pleuritis caused by different administration approach of glucocorticoid.Methods:20 cases were randomly devided into oral and pleurits injection group.30 mg prednisone was given to each patient,then drug concentrations were detected RP-HPLC in blood plasma and pleural fluid after the oral administration of 2,4,6,8 h respectively.The same measures were applied in the other group.The only difference between this two ways is that 10 mg dexametha-sone was injected into the pleural cacity instead of oral administration.Results:No significant differences of drug concentrations in blood plasma and pleuritis fluid were observed at every detected point in both groups.Conclusion:There were no significant drug concentration differences between oral and pleurits injection.Both ways may be considered tuberculous pleuritis therapeutic alternatives.

关 键 词：糖皮质激素 结核性胸膜炎 时相动力学 反相高效液相色谱 

分 类 号：R969.1[医药卫生—药理学] R977.11[医药卫生—药学]