艾灸“肺俞”“膏肓”对BLM_(A5)诱导大鼠肺纤维化的影响  

Effect of moxibustion at Feishu (BL13) and Gaohuang (BL43) on BLM_(A5)-induced interstitial pulmonary fibrosis in rats

作　　者：李戎[1] 闫智勇[2] 李文军[1] 刘春涛[2] 田和炳 张天娥[1] 任玉兰[1] 周蜜娟[1] 李翠霞[1] 李富红[1] 

机构地区：[1]成都中医药大学,四川610075 [2]四川大学华西医学中心 [3]德阳市中医院

出　　处：《中国针灸》2004年第3期204-207,共4页Chinese Acupuncture & Moxibustion

基　　金：四川省自然科学 (中医药类 )重点攻关项目基金资助 (No 0 3SG0 11 0 13 )

摘　　要：目的 :研究艾灸“肺俞”“膏肓”对博莱霉素所致大鼠肺纤维化的阻抑作用 ,为针灸介入肺纤维化防治提供实验依据。方法 :实验用SD大鼠分为 4组 :对照组、模型组、艾灸组、泼尼松组。对照组气管内注入生理盐水 ,其余 3组气管内注入博莱霉素制作大鼠肺纤维化模型。测定分析各组治疗后第 7、14、2 8d肺组织病理学变化以及比较各组第 2 8d肺系数。结果 :艾灸组及泼尼松组肺系数明显减少 (P <0 .0 1) ,肺组织病理学显示肺泡炎及肺纤维化程度均明显减轻。结论 :艾灸“肺俞”“膏肓”对肺间质纤维化具有一定的防治作用。Objective To investigate the effect of moxibustion at “Feishu” (BL 13) and “Gaohuang” (BL 43) on bleomycin-induced pulmonary fibrosis and provide scientific basis for prevention and treatment of pulmonary fibrosis with acupuncture and moxibustion. Methods SD rats were randomly assigned to 4 groups, a control group, a model group, a moxibustion therapy group and a prednisone therapy group. The control group was injected with normal saline via trachea, and the other 3 groups were injected with bleomycin via trachea to induce the exprimental pulmonary fibrosis rat model. Pulmonary pathological changes in each group were investigated on the day 7, 14 and 28 after treatment respectively, and pulmonary coefficients were compared among the groups on the day 28. Results The pulmonary coefficients in the moxibustion therapy group and the prednisone therapy group significantly reduced (P<0.01) and pathological examinations of the lung tissue revealed that the alveolitis and pulmonary fibrosis alleviated significantly. Conclusion Moxibustion at “Feishu” and “Gaohuang” has a certain effect in prevention and treatment of bleomycin-induced pulmonary fibrosis.

关 键 词：博莱霉素 肺间质纤维化 艾灸疗法 组织病理学 

分 类 号：R259.63[医药卫生—中西医结合] R246.1[医药卫生—中医内科学]