环氧司坦对体外培养大鼠黄体形态和功能的影响  

Effect of Epostane on Morphology and Function of Rat Corpora Luteum in Vitro

作　　者：吴晓云[1] 刘昌官[1] 徐斯凡[2] 

机构地区：[1]上海市计划生育科学研究所 [2]江西医学院生理教研室

出　　处：《生殖与避孕》1992年第4期28-30,T002,共4页Reproduction and Contraception

摘　　要：本文观察了环氧司坦(Epostane)对SD大鼠离体黄体组织的形态及孕激素生成的影响。经18 h培养显示环氧司坦有剂量—反应依赖方式抑制hCG促黄体生成孕激素的作用,环氧司坦浓度为10μg/ml时,明显抑制hCG促黄体生成孕激素作用(P<0.01)。对照组和实验组黄体生长良好。当环氧司坦剂量增加到100μg/ml,经培养48 h后表明环氧司坦抑制黄体孕激素基础分泌,还使黄体呈现不同程度的变性和退化,本文结果显示环氧司坦有剂量—反应依赖方式抑制黄体孕酮生成的作用,在一定剂量下有直接融黄体作用。The present experiment studied the effect of epostane on the morphology and the function of corpora luteum. Epostane could inhibit progesterone production in a dosede-pendent manner (0.01-100 μg/ml). When the concentration of epostane was 100 μg/ml, the luteal cells showed degeneration in varying degrees. The study indicates that epostene has a direct luteolytic effect which might be the causes of its interceptive action.

关 键 词：黄体 培养 环氧司坦 孕酮 溶黄体 

分 类 号：R979.21[医药卫生—药品]