花粉多糖注射剂临床前抗肿瘤药效学预试  

Pretesting for Preclinical Antineoplastic Pharmacodymanics of Injection of Pollen Polysaccharides

作　　者：王开发[1] 支崇远[1] 严惠芳[2] 陆宏祺[2] 卜华祥 左其芳 

机构地区：[1]同济大学花粉应用研究中心,上海200092 [2]上海医药工业研究院,上海200437 [3]江苏省科研院所联合发展公司,江苏南京210008

出　　处：《蜜蜂杂志》2004年第6期3-4,共2页Journal of Bee

基　　金：上海市科委现代生物与新药产业发展项目资助(编号:994319131)

摘　　要：花粉多糖对小鼠Lewis肺癌(足趾接种)模型以200mg/kg,100mg/kg,50mg/kg三个剂量iv×10qd方案给药,实验显示高、中、低三个剂量组抑瘤率分别为48.01%,43.09%,31.38%。免疫实验以上述相同的给药方案,花粉多糖对荷Lweis肺癌小鼠NK细胞活性具有明显的提高和促进作用。The model of pollen polysaccharides antineoplastic effect on mouse Lweis lung tumor,inoculating between toes, is a dosage regimen of 3 dosages of iv×10 qd. The rejection rates for Lweis lung tumor are 48.01%,43.09%,31.38% respectively. In the immunologic test with the same kind of dosage regimen, pollen polysaccharides have obvious of promoter active effect for NK cell activity of mice with Lweis lung tumor.

关 键 词：花粉多糖 注射剂 抗肿瘤 药效学 NK细胞 

分 类 号：R96[医药卫生—药理学]