奥曲肽对肝硬化食管胃静脉曲张破裂出血患者血糖代谢的影响  

The effects of octreotide on metabolism of plasma glucose in patients with variceal bleeding

作　　者：许乐[1] 郑小丽[1] 

机构地区：[1]卫生部北京医院消化科,北京100730

出　　处：《中国新药杂志》2004年第5期455-457,共3页Chinese Journal of New Drugs

摘　　要：目的:观察持续静脉点滴奥曲肽对肝硬化食管胃静脉曲张破裂出血患者血糖代谢的影响。方法:奥曲肽100μg静脉推注后,微量泵持续静脉点滴25μg·h-1,使用奥曲肽静脉点滴前及静脉点滴后30,60,120min及d2晨查血糖。结果:172例肝硬化食管胃静脉曲张破裂出血患者静脉点滴奥曲肽后,128例24h内止血,止血成功率74.4%。持续静点奥曲肽治疗中,33例(18.1%)出现糖代谢紊乱,24例(13.9%)血糖升高,9例(5.8%)低血糖,其中1例出现严重低血糖,发生低血糖昏迷。33例出现糖代谢异常患者中,24例合并糖尿病。结论:持续静脉点滴奥曲肽对肝硬化食管胃静脉曲张破裂出血止血效果好,其对糖代谢的影响应引起临床医生的注意,尤其对糖尿病患者,应严密监视血糖变化。Objective:To study the effects of octreotide given by continuously intravenous injec-tion on metabolism of plasma glucose in patients with esophageal variceal bleeding. Methods: Patients were given a continuous infusion of octreotide in a dose of 25μg·h-1 after an initial bolus dose of 100μg and their plasma glucose was measured at 30,60, and 120minutes pre- and post-medication. Results: Within 24h of post-treatment,the variceal bleeding in 128 patients were stopped out of 172 patients, with a successful rate of 74. 4 % . 33 cases of plasma glucose metabolic disorder (18.1% ), 24 cases of hyperglycemia (13.9%), and 9 cases of hypoglycemia (5.8%) including 1 case of hypoglycemia coma occurred during treatment. Among the 33 patients developed plasma glucose metabolic disorder,24 patients were complicated with diabetes. Conclusion: Octreotide given by continuous infusion is very ef-fective in treatment of variceal bleeding but clinical physicians should be aware of that octreotide may affect the plasma glucose metabolism of patients,especially in patients complicated with diabetes.

关 键 词：静脉曲张出血 奥曲肽 血糖 

分 类 号：R969.4[医药卫生—药理学] R977.1[医药卫生—药学]