依布硒的药理作用及反应机制的研究进展  

Recent progress in studies on pharmacological effect and reaction mechanism of ebselen

作　　者：龚平生[1] 罗贵民[1] 

机构地区：[1]吉林大学分子酶学工程教育部重点实验室,吉林长春130023

出　　处：《中国药理学与毒理学杂志》2004年第3期237-240,共4页Chinese Journal of Pharmacology and Toxicology

基　　金：国家自然科学基金资助项目 ( 2 0 0 72 0 10 )~~

摘　　要：依布硒是一种小分子抗氧化剂 ,易于参加各种氧化还原反应 ,能清除机体内过多的过氧化物 ,阻断产生自由基的链式反应 ,因此可治疗多种疾病 ,维持机体的正常生理功能。长期以来 ,人们普遍认为依布硒在体内主要通过模拟谷胱甘肽过氧化物酶的反应机制发挥作用。然而 ,近来的研究表明依布硒在体内更趋向于通过硫氧还蛋白还原酶和硫氧还蛋白反应系统来发挥作用。Ebselen 〔2 phenyl 1,2 benzisoselenal 3(2H) one〕 is a low molecular seleno organic antioxidant, which is apt to participate various redox reactions. Ebselen can eliminate the reactive oxygen species in the organism, so it can be used as a valuable supplement to the natural antioxidant enzymes to cure many diseases and keep the normal function of organisms. The reaction mechanism of ebselen similar with action of glutathione peroxidase has been accepted for a long time. But, some results have brought us a novel mechanism, that is ebselen exerts antioxidant action more likely through the thioredoxin reductase and thioredoxin system. This review briefly summarizes the pharmacological effects and reaction mechanism of ebselen.

关 键 词：依布硒 脂质过氧化 谷胱甘肽过氧化物酶 硫氧还蛋白还原酶 硫氧还蛋白 

分 类 号：R963[医药卫生—微生物与生化药学]