普罗帕酮治疗儿童心肌病心律失常疗效观察  

Propafenone on arrhythmia

作　　者：肖燕芳[1] 张双船[1] 张萍[1] 

机构地区：[1]北京大学深圳医院,广东深圳518036

出　　处：《罕少疾病杂志》2004年第3期11-12,共2页Journal of Rare and Uncommon Diseases

摘　　要：目的探讨普罗帕酮治疗小儿心肌病心律失常的疗效,以及普罗帕酮治疗26例心肌病中不同心律失常的疗效差别。方法对26例儿童心肌病心律失常患者进行普罗帕酮治疗前后血浆心钠素(ANP)浓度、心脏指数(CI)变化的观察,并对观察各数据进行分析。结果心律失常发作时心肌病患儿血浆ANP浓度明显高于正常对照组和转复后、CI则明显低于正常对照组和转复后(P<0.05)。心肌病患儿在心律失常发作时血浆ANP和CI之间有良好的相关关系(r1=0.602,r2=0.759,P<0.05)。静脉注射普罗帕酮后室上性心动过速组(含心房扑动)的转复率明显高于室性心动过速组(P<0.05)。心肌病用药过程中无1例病情加重。结论普罗帕酮是治疗小儿心肌病心律失常安全有效的药物,虽然总体疗效稍差。Objective To investigate the effects of propafenone on arrhythmia and thedifferences of treatment effects on varity of cardiomyopathy.MethodsThe clinical data ofpropafenone on 26 children with cardiomyopthy were analyzed retrospectively.ResultsAsarrhythmia onsetted,atrial natriuretic peptide(ANP) concentration in patients with cardiomyopathywas higher than that in normal group and recovery group, while cardiac index (CI) waslower.The relationship between atrial natriuretic peptide and cardiac index wasclose.ConclusionPropafenone is a kind of safe medicine for treatment of cardiomyopathy.[

关 键 词：普罗帕酮 心律失常 心肌病 心钠素 心脏指数 

分 类 号：R972.2[医药卫生—药品] R541.7[医药卫生—药学]