鼻息肉中MMP-9和NF-κB的表达研究  

Study to the expression of nuclear factor κB and MMP-9 in nasal polyps

作　　者：王天生[1] 孙虹[1] 陈江波[1] 柳岸[1] 秦作荣[1] 

机构地区：[1]中南大学湘雅三医院耳鼻咽喉科,湖南长沙410013

出　　处：《中国耳鼻咽喉颅底外科杂志》2004年第2期80-82,共3页Chinese Journal of Otorhinolaryngology-skull Base Surgery

基　　金：湖南省自然科学基金项目 ( 0 1JJY2 0 92 );湖南省卫生厅资助项目 ( 2 0 0 1-T48)

摘　　要：目的　研究鼻息肉MMP 9和NF κB的表达及其意义。方法　应用免疫组化的方法检测正常鼻黏膜和鼻息肉MMP 9和NF κB的表达 ,图像分析系统进行半定量。结果　MMP 9在正常对照组中有弱阳性表达 ,而鼻息肉组的表达显著增强 ,主要在上皮细胞、炎症细胞、内皮细胞和腺上皮细胞中表达。NF κB在正常对照组的胞浆呈弱阳性表达 ,而在鼻息肉的上皮细胞、炎症细胞和间质细胞的细胞核内表达呈强阳性 ;两种因子表达显著相关。结论　NF κB和MMP 9的表达可能对鼻息肉的发生和发展有重要作用 ,而且在鼻息肉中NF κB可能对MMP 9的表达也有调控作用。Objective To study the expression and function of matrix metalloproteinase-9 and transcription factor nuclear factor κB in nasal polyps. Method The expression of NF-κB and MMP-9 was observed in the way of immunohistochemistry. Image analysis system to semiquantity and the correlation analysis was done. Result In nasal polyps, the expression of MMP-9 was weak and NF-κB was mainly expressed in cell plasma. These two cytokines were significantly stronger while NF-κB was strongly expressed in nuclei. Conclusion NF-κB and MMP-9 might play an important role in the development of nasal polyps and MMP-9 may be regulated by NF-κB in transcriptional.

关 键 词：鼻息肉 核因子ΚB 基质金属蛋白酶 免疫组化 

分 类 号：R765.25[医药卫生—耳鼻咽喉科] R392.31[医药卫生—临床医学]