^(131)I治疗非毒性甲状腺肿的临床评价  

The clinical evaluation of nontoxic goiter after ^(131)I therapy

作　　者：段东[1] 罗加[1] 李建国[1] 李小放[1] 

机构地区：[1]重庆医科大学第一附属医院核医学科,400016

出　　处：《中国地方病学杂志》2004年第3期251-252,共2页Chinese Jouranl of Endemiology

摘　　要：目的对131I治疗非毒性甲状腺肿(NTG)进行临床评价。方法对35例经临床确诊的NTG患者,采用131I治疗,随访1年以上,观察临床疗效及近期副作用。结果35例NTG患者,治愈14例,有效19例,无效2例,甲低15例;治愈率和总有效率分别为40%和94.3%,甲低发生率为42.9%;治疗1年后甲状腺平均缩小60.2%。治疗后除部分患者出现一过性的颈部肿胀及甲亢表现外,未见其他明显的近期不良反应。结论131I治疗NTG疗效肯定、简便、相对安全。对甲状腺肿大明显,甲状腺制剂治疗无效,且不愿接受手术的NTG患者,131I治疗是值得推荐的方法。Objective To evaluate the therapy of nontoxic goiter with 131I. Methods Thirty-five patients with nontoxic goiter were treated with 131I, and the clinical curative effects and side effects were observed for more than 1 year follow-up. Results Fourteen cases (40%) were once cured among the 35 patients,improvement in 19 (54.3%) cases, ineffective in 2 (5.7%) cases, hypothyroidism in 15(42.9%) cases. The average weight of thyroid was decreased about 60.2% of all patients. Despite temporary swelling of the thyroid and symptoms of hyperthyroidism, there were no other side effects found in all patients. Conclusions 131I is found to be an effective, simple and safe treatment of nontoxic goiter. Especially to the patients with obvious goiter, or ineffective with thyroid hormone preparation and unwilling to accept surgery therapy, it should be the preferred mode of therapy.

关 键 词：^131I 治疗 非毒性甲状腺肿 副作用 碘放射性同位素 

分 类 号：R581.3[医药卫生—内分泌]