木芙蓉叶有效组分对大鼠肾缺血再灌注损伤的保护作用  

Effect of Leaves of Hibiscus mutabilis L.on Renal Ischemia Reperfusion Injury of Rat Model

作　　者：符诗聪[1] 罗仕华[1] 周玲珠[2] 张凤华[1] 

机构地区：[1]上海第二医科大学附属瑞金医院伤科,上海伤骨科研究所,上海市200025 [2]上海第二医科大学附属瑞金医院生化室,上海市200025

出　　处：《广西科学》2004年第2期131-133,共3页Guangxi Sciences

基　　金：上海市教委资助重点课题 (课题编号 :0 1B11)

摘　　要：为了探讨木芙蓉叶有效组分 (MFR)对大鼠肾缺血再灌注损伤中的作用 ,采用大鼠肾缺血再灌注模型 ,木芙蓉叶有效组分灌胃给药 ,观察血清尿素氮 (BUN)、肌酐 (Scr)及肾组织病理变化 ,并检测白细胞介素 - 1(IL- 1 )的含量。结果再灌注 2 4 h后 ,治疗组血 BUN及 Scr明显降低 (P <0 .0 5 ) ;治疗组血液 IL- 1含量与非治疗组相比有显著性差异 (P <0 .0 5 ) ;而且治疗组肾组织病理损伤较非治疗组明显减轻。木芙蓉叶有效组分对肾缺血再灌注损伤有保护作用 ,其原因可能与抑制 IL-To explore the role of effective fraction of Hibiscus mutabilis L (MFR) on renal ischemia reperfusion injury in rat Using a model of renal ischemia reperfusion injury,determined the change of blood urea nitrogen (BUN),serum creatinine(Scr),the pathological change of kidney tissue and the level of interleukin 1(IL 1) after the Hibiscus mutabilis L was administrated Results At 24 h after reperfusion,the BUN and Scr level decreased significantly in MFR group (P<0 05) The level of IL 1 was marked difference between MFR group and blank group (P<0 05) The renal pathological injury of MFR group was mitigated significantly The results suggest that Hibiscus mutabilis L protects kidney from ischemia reperfusion injury,and that this action may underline its inhibitory action on the interleukin 1 releasing

关 键 词：有效组分 木芙蓉叶 肾缺血再灌注 血清尿素氮 肌酐 白细胞介素-1 

分 类 号：R965.3[医药卫生—药理学] Q949.757.3[医药卫生—药学]