组织酸化参与外周痛觉传递的离子通道机制  

Ion Channels Mediate Proton Transduction in Peripheral Pain Perception

作　　者：伍龙军[1] 徐天乐[2] 

机构地区：[1]中国科学院上海生命科学研究院神经科学研究所,上海200031 [2]中国科学技术大学神经生物学与生物物理学系,合肥230027

出　　处：《生物化学与生物物理进展》2004年第5期393-397,共5页Progress In Biochemistry and Biophysics

摘　　要：组织酸化可以导致痛觉的产生 .初级感觉神经元可以通过离子通道来感受外周的组织酸化 .已鉴定了几个离子通道家族可能参与了外周组织酸化的感受 :a 酸敏感离子通道 (ASICs)是可以被酸直接门控的阳离子通道 ;b 辣椒素受体 (VR1)可被酸敏化 ,同时可被pH <6 0直接激活 ;c P2X2和P2X2 / 3受体通道反应被酸上调 ;d TwIK相关的酸感受钾通道 (TASK)是被酸关闭的双孔内向整流钾通道 .这些通道被酸所调控的共同结果就是提高了神经元的兴奋性 .因此 。Tissue acidosis can directly induce pain sensation which is mediated by ion channels in peripheral sensory neurons. To date, several ion channel superfamilies are identified to be involved in the pain from tissue acidosis. ( 1) ASICs can be gated by proton and directly mediate the acidosis pain; (2) VR1 can be sensitized by acidosis as well as activated by pH < 6.0; (3) P2X2 receptor is up-modulated whereas P2X3 is down-modulated by acidosis; (4) TASK is one of the tandem pore and the inwardly rectifying K+ channel which can be closed by acidosis.

关 键 词：痛觉 组织酸化 离子通道 

分 类 号：Q42[生物学—神经生物学] Q51[生物学—生理学]