补肾益精方药对老年大鼠不同组织DNA TOPOⅡ活性的影响  

Effect of Prescriptions for Tonifying Kidney and Benefiting Essence of Life on Topoisomerase Ⅱ Activity of the Different Organs of Senile Rats

作　　者：崔成德[1] 张杰[1] 李溳[1] 徐琦[1] 

机构地区：[1]中国中医研究院基础理论研究所,北京100700

出　　处：《中国中医基础医学杂志》2004年第5期47-49,共3页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：国家自然科学基金资助项目 (3 0 0 70 95 9)

摘　　要：目的 :研究补肾益精方药对老龄大鼠肝、肾、睾丸、脾DNATOPOⅡ活性的影响 ,初步探讨补肾益精方药抗衰老的机理。方法 :用雄性老年大鼠为肾虚模型 ,观察左归饮、益肾宝对TOPOⅡ活性的影响。结果 :老年大鼠TOPOⅡ的活性明显低于青年大鼠 ,经灌喂左归饮、益肾宝后 ,老年大鼠TOPOⅡ的活性显著提高。结论 :补肾益精方药能提高老年大鼠TOPOⅡ的活性 ,起到延缓衰老的作用。Objective:To study effect of prescriptions for Tonifying Kidney and Benefiting Essence of life on topo Ⅱ activity of liver, kidney, testis and spleen of senile rats.Methods:Using male, old senile rats as models of Kidney-Asthenia,the effect of Zuoguiyin and YishenBao on topo Ⅱ activity was observed.Results:Topo Ⅱ activity of senile rats was distinctly lower than those of young rat group.After above-mentioned two prescriptions were given to the senile rats,topo Ⅱ activity of the senile rats obviously increased.Conclusions:Both Zuoguiyin and Yishenbao could promote topo Ⅱ activity of senile rats and prolong life.

关 键 词：补肾益精方药 老年人 大鼠 DNA TOPOⅡ 中医 

分 类 号：R289[医药卫生—方剂学]