地塞米松治疗妊娠肝内胆汁淤积症45例分析  

Study on effects of dexamethazone in intrahepatic cholestasis of pregnancy

作　　者：刘建[1] 董晓静[1] 蔡汉中[1] 

机构地区：[1]重庆医科大学附属第二医院,400010

出　　处：《重庆医学》2004年第5期690-692,共3页Chongqing medicine

摘　　要：目的　评价地塞米松对ICP孕妇的治疗效果及对围生儿预后的影响。方法　随机抽取 86例ICP孕妇进行前瞻性研究 ,观察组 4 5例给予地塞米松 9mg/d口服 ,7d为 1疗程。对照组 4 1例常规给予输液及营养药物治疗。比较两种治疗对临床症状改善、肝功能和总胆酸水平的影响以及围生儿预后。结果　地塞米松治疗组血清TBA水平较对照组有明显下降 (P <0 .1 ) ,87.5 0 %的患者瘙痒明显缓解 (P <0 .0 1 ) ,无病情加重患者。且胎龄较对照组明显延长 (P <0 .0 1 ) ,羊水浑浊及重度新生儿窒息发生率亦低于对照组 (P均 <0 .0 1 ) ,无新生儿缺血缺氧性脑病发生 (P <0 .5 )。结论　地塞米松能有效改善ICP的瘙痒症状及围生儿预后 ,并且无明显副作用 ,可作为ICP治疗的首选药物。Objectives To evaluate the therapeutic effect of dexamethazone on pregnant women with ICP and the influence on prognosis of perinatals. Methods To draw 86 pregnant women with ICP randamly to do perspective study. The study group(45) was given dexamethazone by taken orally 9 12mg per day for 7d as one period of treatment. The control group(41) was given generally transfusion and energic treatment. To compare the improvement of clinical symptom, the change of liver function and the level of total cholic acid as well as the prognosis of perinatals in these two groups after treatment.Results The level of TBA in serum was declined markedly in study group with dexamethazone than that in control group( P <0.1). The symptom of itch in 87.5 percent of patients were alleviated obviously( P <0.01). No patient was deteriotated. The age of fetus was prolonged obviously than control group( P <0.01). The occurent rates of meconium stained amnioricfluid and heavy asphyxia neonatorum in study group were lower than those in control group( P <0.01). Hypoxic ischemic encephalopathy was not occured in any newborns( P <0.05). Conclusion The symtom of itch and prognosis of perinatals in pregnant women with ICP could be ameliorated by dexamethazone, which was no obvious side effects and could be the first optional drug in ICP.

关 键 词：妊娠 胆汁淤积 地塞米松 母儿预后 治疗效果 

分 类 号：R714146[医药卫生—妇产科学]