甘草酸二铵对大鼠环磷酰胺损伤的保护作用  

Protective effect of diaminonium glycyrrhizinate on cyclophosphamide injured rats

作　　者：江南[1] 刘翠霞[2] 但汉雄[2] 王蓉[2] 

机构地区：[1]武汉大学药学院 [2]湖北药检高等专科学校

出　　处：《中国临床药理学与治疗学》2004年第3期326-328,共3页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的 :研究甘草酸二铵对大鼠环磷酰胺损伤的保护作用。方法 :实验随机分为 3个甘草酸二铵组、正常组和对照组。分别给大鼠 0 .5 %甘草酸二铵 (2 0、4 0、6 0mg·kg-1,ig)和生理盐水连续 9d。d 6、d 7、d 8给药后 1h ,各给药组和对照组ip环磷酰胺 15 0mg·kg-1,检测血液白细胞、红细胞、血小板、总蛋白、球蛋白、白蛋白水平以及心脏、肾、肝脏组织脂质过氧化产物丙二醛含量 ,同时检测各组的凝血时间。结果 :甘草酸二铵能够抑制环磷酰胺引起的血液白细胞、红细胞、血小板、总蛋白、球蛋白、白蛋白的降低 ,明显降低心脏、肾、肝脏组织丙二醛的含量。甘草酸二铵对由环磷酰胺引起的凝血时间延长也有治疗作用。结论 :甘草酸二铵对大鼠环磷酰胺损伤有保护作用。AIM: To study the protective effect of diaminonium glycyrrhizinate (DG) on cyclophosphamide(CP)injured rats. METHODS: The experiments were randomly divided into 3 DG groups, the normal group and the control group. After administered ig 0.5 % DG (20,40, 60 mg·kg -1 ) or equal amount of distilled water to rats for 9 d, the control group and DG groups were given CP ( 150 mg·kg -1 ) once a day on the 6th, 7th and 8th day. The Level of white blood cell (WBC), red blood cell (RBC), platelet (PLT), total protein (TP), globulin (GLO), albumin (ALB) and the content of malondial hydride(MDA) produced by lipid peroxidatio in heart, liver, and kidney tissue were observed respectively. The values of coagulation time of blood in each group were examined. RESULTS: DG obviously inhibited the decrease of WBC, RBC, PLT, TP, GLO, and ALB, and the content of MDA was also decreased in heart, kidney and liver tissue. CONCLUSION: DG protects the rats from cyclophosphamide injured.

关 键 词：甘草酸二铵 白细胞 总蛋白 凝血时间 丙二醛 

分 类 号：R285.5[医药卫生—中药学]