冠心病患者血浆尾加压素Ⅱ的临床研究  

Clinical study of plasma urotensin Ⅱ in patients with coronary heart disease

作　　者：方石虎[1] 李志樑[1] 吴宏超[1] 唐朝枢[2] 陆青[1] 刘海潮[1] 严全能[1] 

机构地区：[1]第一军医大学珠江医院心血管内科,广东广州510282 [2]北京大学第一医院心血管研究所,北京100034

出　　处：《第一军医大学学报》2004年第5期563-565,共3页Journal of First Military Medical University

基　　金：国家重大基础发展研究项目(973子课题;G200056905)~~

摘　　要：目的探讨血管活性物质尾加压素Ⅱ(UⅡ)在冠心病患者体内的表达及其变化。方法采用放射免疫法测定50例冠心病患者及20例健康体检者的血浆UⅡ的水平。结果(1)健康对照组静脉血浆UⅡ含量为3.70±1.30 pg/ml,冠心病患者的血浆UⅡ含量为1.61±1.02 pg/ml,两者有统计学差异(P=0.000)。冠心病患者中稳定性心绞痛者血浆UⅡ含量为2.62±1.20 pg/ml,不稳定心绞痛者UⅡ含量为1.39±0.80 pg/ml,急性心肌梗死者UⅡ含量为1.04±0.45 pg/ml,3组之间有显著性差异(P=0.004)。(2)冠心病患者中冠脉血管有闭塞组静脉血浆UⅡ含量为1.29±1.02 pg/ml,单纯狭窄组UⅡ含量为1.76±1.00 pg/ml,两者无统计学差异(P=0.131)。(3)经皮腔内冠状动脉成型术(PTCA)及支架植入术后,出现再狭窄患者组血浆UⅡ含量为2.28±0.94 pg/ml,而其他病人的血浆UⅡ含量为1.40±0.96 pg/ml,两者有统计学差异(P=0.008)。(4) PTCA治疗前后,股动脉血浆UⅡ的含量分别为1.18±1.14、2.22±1.77 pg/ml,两者有统计学差异(P=0.001)。结论UⅡ可能参与了冠心病的发病;在PTCA治疗后出现支架内再狭窄中可能起作用。Objective To investigate the changes in plasma urotensin Ⅱ(UⅡ) expression levels in patients with coronary heart disease (CHD). Methods Plasma UⅡ levels in 50 CHD patients with coronary stenosis indicated by coronary angiography and 20 healthy subjects were determined by radio immunoassay. Results Venous plasma UⅡ levels were significantly lowered in CHD patients in comparison with tthe healthy subjects (1.61±1.02 pg/ml vs 3.70±1.30 pg/ml, P=0.000). In the CHD patient group, significantly differences were noted in the UⅡ levels between patients with stable angina (2.62±1.20 pg/ml), unstable angina (1.39±0.80 pg/ml) and acute myocardial infarction (AMI, 1.04±0.45 pg/ml, P=0.004). CHD patients with coronary artery occlusion and those with only coronary stenosis had comparable venous plasma UⅡ levels (1.29±1.02 pg/ml vs 1.76±1.00 pg/ml, P=0.131), whereas the patients with restenosis after percutaneous transluminal coronary angioplasty (PTCA) had higher UⅡ levels than the other subjects in the CHD patient group (2.28±0.94 pg/ml vs 1.40±0.96 pg/ml, P=0.008), and the femoral plasma UⅡ levels were significantly elevated after PTCT, increasing from 1.18±1.14 pg/ml to a postoperative level of 2.22±1.77 pg/ml (P=0.001). Conclusion UⅡ might play a role in the pathophysiological process of CHD and can be involved in the restenosis after angioplasty.

关 键 词：冠心病 血浆 尾加压素Ⅱ 临床研究 血管活性肽 再狭窄 

分 类 号：R541.4[医药卫生—心血管疾病]