hs-CRP与TC/HDL-C联合检测在冠心病诊断中的应用  

Detection of high-sensitivity C-reactive protein and total cholesterol/high-density lipoprotein cholesterol ratio for diagnosis of coronary artery disease

作　　者：姜朝新[1] 李志樑[2] 严全能[2] 

机构地区：[1]第一军医大学珠江医院检验科,广东广州510282 [2]第一军医大学珠江医院心内科,广东广州510282

出　　处：《第一军医大学学报》2004年第5期576-578,共3页Journal of First Military Medical University

基　　金：国家重大发展基础研究项目(973)子课题(G200056905)~~

摘　　要：目的探讨超敏C-反应蛋白(hs-CRP)和总胆固醇/高密度脂蛋白胆固醇比值(TC/HDL-C)联合检测对冠状动脉粥样硬化性心脏病(CHD)的预测价值。方法对240例CHD患者和40例健康对照者进行血清hs-CRP和TC、HDL-C测定、分析。结果CHD患者血清hs-CRP浓度和TC/HDL-C比值均显著高于对照组(P<0.01)。联合应用hs-CRP和TC/HDL-C比值2种指标判别,对CHD患者的诊断阳性率(95.0%)高于分别应用hs-CRP(85.0%)、TC/HDL-C(76.7%)单一指标。结论应用hs-CRP和TC/HDL-C比值联合检测,更有助于冠心病的早期诊断。Objective To study the value of detecting high-sensitivity C-reactive protein (hs-CRP) combined with determination of total cholesterol/high-density lipoprotein cholesterol (TC/HDL-C) in the diagnosis of coronary artery disease (CHD). Methods A total of 240 patients with documented CHD and 40 healthy subjects were enrolled in this study for measurement of serum concentrations of hs-CRP, TC and HDL-C. Results The concentration of hs-CRP and TC/HDL-C ratio was significantly higher in CHD patients than in the control subjects (P<0.01). The positivity rate by detecting both the two markers (0.950) was higher than that of single marker detection of either hs-CRP (0.850) or TC/HDL-C (vs 0.767). Conclusion Detection of hs-CRP combined with determination of TC/HDL-C may facilitate early diagnosis of CHD.

关 键 词：HS-CRP TC/HDL-C 联合检测 冠心病 诊断 

分 类 号：R541.4[医药卫生—心血管疾病]