实验性大鼠颅脑损伤后血清SOD和NO的变化  

Experimental Study on Changes of Serum SOD and NO Level in Rats Following Traumatic Brain Injury

作　　者：李玉红[1] 闫平[1] 李汝霖[2] 孟晓萍[1] 何远[1] 王春[1] 

机构地区：[1]武汉大学医学院法医学教研室,武汉430071 [2]武汉大学医学院公共卫生学院,武汉430071

出　　处：《武汉大学学报（医学版）》2004年第3期306-308,313,共4页Medical Journal of Wuhan University

摘　　要：目的 :测定颅脑损伤大鼠伤后不同时间血清中SOD活力和NO的浓度变化 ,探讨其在脑外伤发病机制中的作用及随损伤时间的变化规律。方法 :建立大鼠颅脑损伤动物模型 ,测定损伤后不同时间大鼠血清中的SOD活力和NO浓度变化 ,并与正常对照组进行比较。结果 :观测了SOD活力和NO浓度两项指标在伤后 2 1d血清中的变化情况 ,发现SOD活力在伤后立即下降 ,第 7d时降至最低 ,然后上升 ,直至伤后第 2 1d ;NO浓度在伤后 3h水平降至最低 ,后又上升 ,至伤后第 7d时升至最高水平 ,然后下降 ,至伤后第 2 1d ,基本恢复正常水平。结论 :SOD和NO在颅脑损伤的病理过程中有重要作用 ,且二者在损伤过程中存在一定变化规律 。Objective: To investigate the pathology mechanism and changes of SOD and NO in brain contusion. Methods: Brain contusion models were established, blood SOD and NO level of 55 rats was determined. Experimental rats were divided into groups according to the contusion time. Results:The activity of SOD decreased immediately after contusion,came to the lowest point after 7 days, then increased in the following 2 weeks. The density of NO came to the lowest point after 3 h, tthen increased to peak after 7 days, and it came to the same level at 21 day compared to that in the control group. Conclusion:Serum levels of SOD and No can be used to predict the contusion time in traumatic brain injury.

关 键 词：颅脑损伤 超氧化物歧化酶 一氧化氮 

分 类 号：R651.15[医药卫生—外科学]