喉咽清水蜜丸的研制及其药效学和毒理学研究  

Preparation,Pharmacodynamics and Toxicology of Houyanqingshui Honeyed Pills

作　　者：张一飞[1] 曲福军[1] 吴琳华[1] 邱晓红 

机构地区：[1]哈尔滨医科大学附属第二医院临床药学药物研究所,哈尔滨市150086 [2]哈尔滨市公安医院,哈尔滨市150001

出　　处：《中国药房》2004年第2期78-80,共3页China Pharmacy

基　　金：黑龙江省科技厅"九五"重大科研项目 (G96C20-19)

摘　　要：目的 :研究喉咽清水蜜丸的制备、质量控制方法及其药效学和毒理学。方法 :采用高效液相色谱法测定喉咽清水蜜丸中甘草酸的含量 ;对制剂的抗炎、镇痛、祛痰作用进行研究 ;对制剂的急性毒性和长期毒性进行研究。结果 :喉咽清水蜜丸中甘草酸的线性范围为0 0384～0 615mg/ml ,回收率为 (99 20±1 75) %。本制剂具有抗炎、镇痛、祛痰作用 ,未见明显急性毒性和长期毒性。结论 :本制剂制备工艺简单 ,质量可控 ,疗效确切 ,安全性较高。OBJECTIVE:To study the preparation,quality control,pharmacodynamics and toxicology of Houyanqingshui honeyed pills(HHP).METHODS:The content of glycyrrhizic acid in HHP was determined with HPLC;the anti-inflammatoˉry,analgesic and expectorant actions of this preparation and the acute and long-term toxicity were observed.RESULTS:The linear range of glycyrrhizic acid in HHP was0.0384～0.615mg/ml.The recovery was(99.20±1.75)%.The preparation had anti-inflammatory,analgesic and expectorant actions and to obvious acute and long-term toxicity was found.CONCLUSION:HHP is simple in preparation technic,controllable in quality,reliable in therapeutic effect and safe in use.

关 键 词：喉咽清水蜜丸 甘草酸 药效学 毒理学 

分 类 号：R944[医药卫生—药剂学] R96[医药卫生—药学]