高分子聚合物水凝胶HFMC对人精子染色体的影响  

THE EFFECTS OF HIGH POLYMER HYDROGEL HFMC ON THE CHROMOSOMES OF HUMAN SPERMATOZOA

作　　者：崔晓[1] 罗自强[1] 黄天华[2] 漆著[2] 李丹[2] 

机构地区：[1]华西医科大学生理学教研室 [2]四川省计划生育科学研究所

出　　处：《中华医学遗传学杂志》1992年第3期142-145,T010,共5页Chinese Journal of Medical Genetics

基　　金：国家自然科学基金;四川省计划生育委员会资助项目

摘　　要：高分子聚合物水凝胶甲基丙烯酸乙酯-甲基丙烯酸-甲基丙烯酸羟乙酯(简称HFMC)具有可通透性和自然复孕两大特性,用作输精管节育材料有广泛的应用前景。为了检测它是否具有潜在的遗传毒性,应用人精子染色体离体测试系统,用经HFMC处理后的人精子与去透明带金黄地鼠卵受精,然后分析精子的染色体核型。结果HFMC各剂量组与阴性对照组相比,染色体结构畸变精子率均无显著差异(P>0.05),而阳性对照组却极显著高于阴性对照组(P<0.05)。提示HFMC作为一种安全的高分子男性节育材料值得深入研究。HFMC is a kind of high polymers which could be used formale contraception by injecting it into the deferent ducts. To evaluate the potential genetic risk of HFMC, 521 karyotypes of human sperm chromosomes were analyzed, using zonafree hamster eggs penetrated in vitro by human spermatozoa after being treated with 3 dosages of HFMC. The results showed that the rates of sperm with structural chromosome aberrations for the 3 dosage groups of HFMC were not significantly different from that of the control (P>0.05), but those of the Pingyangmycin (positive agent) group were statistically higher than that of the control (P<0.01).

关 键 词：高分子聚合物 精子 染色体 

分 类 号：R321.1[医药卫生—人体解剖和组织胚胎学]