健胃愈疡颗粒剂对乙酸诱导的大鼠胃溃疡愈合过程中TGF-β1表达的影响  

Effects of Jianwei Yuyang Granule on TGF-β_1 Expression during the Healing Process of Rat Gastric Ulcer Induced by Acetic Acid

作　　者：周勇杰[1] 李家邦[1] 廖书胜[1] 杨冬花 周兵[1] 

机构地区：[1]中南大学湘雅医院中西医结合研究所,湖南长沙410078

出　　处：《中国医师杂志》2004年第6期724-726,共3页Journal of Chinese Physician

基　　金：湖南省科学技术厅科技计划重点项目 (0 2SSY1 0 0 5 - 4 )

摘　　要：目的　研究乙酸诱导的大鼠胃溃疡愈合过程中 ,健胃愈疡颗粒剂 (JWYY)对转化生长因子 (TransforminggrowthfactorTGF) -β1 表达的影响。方法　用Okabe改良法复制大鼠胃溃疡模型 ,采用免疫组织化学技术检测TGF -β1 的表达。结果　溃疡愈合过程中TGF -β1 的表达JWYY组较正常组和模型组显著升高 ,与法莫替丁 (FMTD)组比较差别有显著性。结论　TGF -β1 胃溃疡愈合中表达显著增高 ,尤其在JWYY组表达增高 ,因此JWYY可能通过增高TGF -β1Objective To study the effects of Jianwei Yuyang granule on TGF-β 1 expression in the healing process of rat gastric ulcer induced by acetic acid. Methods Animal model of gastric ulcer in rat was set up with the modified Okabe's method, and the TGF-β 1 expression in the gastric ulcerated tissues was detected by immunohistochemical technique. Results TGF-β 1 expression in gastric ulcerated tissues during the healing process in Jianwei Yuyang group significantly increased compared with the normal, model and famotidine treatment groups. Conclusion TGF-β 1 expression in gastric ulcerated tissues induced by acetic acid during the healing process significantly increased,especially in Jianwei Yuyang group. Jianwei Yuyang granule may accelerate gastric ulcer healing by increasing TGF-β 1 expression in gastric ulcerated tissues.

关 键 词：健胃愈疡颗粒剂 乙酸诱导 大鼠 胃溃疡 TGF-Β1 JWYY 消化性溃疡 

分 类 号：R285[医药卫生—中药学]