精氨酸-胍基丁胺代谢的研究进展  

Advances in the research of arginine-agmatine metabolism

作　　者：曹学武[1] 高钰琪[1] 

机构地区：[1]第三军医大学病理生理与高原生理学教研室,重庆400038

出　　处：《生命科学》2004年第3期170-172,共3页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(30170405)

摘　　要：近几年来,随着对精氨酸代谢的研究,发现除了存在精氨酸-一氧化氮代谢途径外,还存在着精氨酸-胍基丁胺代谢途径。该反应由精氨酸脱羧酶催化,在体内有广泛的分布。这两条代谢途径间存在着密切的相互调节关系。Arginine metabolism plays important roles in development, physiology and pathophysiology. Manyrecent studies have shown that there is a novel alternate arginine metabolic pathway (L-arginine-agmatine)besides the pathway (L-arginine-nitric oxide). Agmatine is an amine derived from the decarboxylation of argin-ine by arginine decarboxylase (ADC). Agmatine and arginine decarboxylase have been recently identified invarious mammalian organs and tissues. There is a close inter-regulation between the two pathways for argininemetabolism.

关 键 词：精氨酸 胍基丁胺 精氨酸脱羧酶 

分 类 号：Q517[生物学—生物化学]