Alzheimer病注意缺陷的功能MRI研究  

Functional MRI Studies of Attentional Deficit of Alzheimer's Disease

作　　者：郝晶[1] 李坤成[1] 王葳[1] 杨彦辉[1] 陈骐[2] 王岩[2] 

机构地区：[1]首都医科大学宣武医院放射科,北京100053 [2]北京大学脑科学与认知科学中心,心理学系,北京100871

出　　处：《同济大学学报（医学版）》2004年第3期205-208,共4页Journal of Tongji University(Medical Science)

摘　　要：目的　采用事件相关功能磁共振成像(event related functional MRI,ER-fMRI)方法考察AD患者脑内负责空间注意定向及解决干扰效应神经机制的特点,并进一步探讨AD与正常老年对照组前后注意网络相互作用的差异。方法　对12例AD和10例正常老年对照组进行了视觉定向中返回抑制效应与Stroop色词任务相结合的实验测试,同时采用Siemens Sonata 1.5 T成像系统,采集其脑部的BOLD-fMRI数据,通过 SPM软件进行统计分析得到脑功能活动的图像。结果　12例AD受试者中 10 例及全部对照组的资料符合研究条件而被采用。AD患者和正常老年对照组在单独完成 Stroop和 IOR 任务时,脑区激活模式相似。结论　AD 患者和正常老年对照组的Stroop干扰效应均受注意的调节,但注意调节的神经机制很可能是不同。Objective To investigate the neural correlates of spatial attentioan orientation and interference control in AD patients and to investigate AD and controls about the possible difference of the interaction between the anterior and posterior attention network with event-related functional MRI.Methods Twelve probable patients with Alzheimer's disease and 10 normal old controls participated in the experiment designed with inhibition of return in visual orienting and Stroop color-word interference effect.The fMRI data were collected on Siemens 1.5 T Sonata MRI systems and analyzed by SPM to generate the activation map.Results The data sets from 10 of 12 AD and all controls were used in the study.Conclusion AD patients activated left superior parietal lobe,inferior parietal lobule,left frontal gyrus and bilateral medial temporal lobes.But controls activated bilateral superior parietal lobes,frontal gyrus and right thalamus.Conclusion Attention modulates both normal people's and AD patients' interference control,but probably with different neural mechanisms.

关 键 词：功能磁共振成像 注意网络 大脑 ALZHEIMER病 

分 类 号：R817.8[医药卫生—影像医学与核医学]