68例HBsAg阳性产妇初乳中HBVDNA定量检测的临床意义  

Significance of quantitative detection of HBVDNA in HBsAg-positive maternal colostrum

作　　者：解良娟 张帮骤[2] 张璠[1] 杨国福[2] 史晓红[3] 

机构地区：[1]太原市传染病医院妇产科,太原030012 [2]中山大学安达基因诊断中心 [3]山西医科大学公共卫生学院

出　　处：《山西医科大学学报》2004年第3期287-289,共3页Journal of Shanxi Medical University

基　　金：山西省自然科学基金资助项目 ( 2 0 0 0 10 63 )

摘　　要：目的　探讨HBsAg阳性产妇能否进行母乳喂养。 方法　选择住院分娩的HBsAg阳性产妇 6 8例 ,收集其产后 2～ 5d母体静脉血及初乳 ,检测母血乙肝病毒标志物 (HBV M)和HBVDNA以及初乳HBVDNA。结果　母血清HBeAg阳性、HB VDNA阳性者母乳中HBVDNA检测阳性率高 ,而HBeAg阴性、HBVDNA阴性者初乳中排毒率低 ,两组比较差异有高度显著性 (P <0 .0 1)。结论　母血HBeAg、HBVDNA阳性组母乳中排毒率高 ,不宜母乳喂养。而HBeAg及HBVDNA阴性组母乳中排毒低 ,可以哺乳 ,但应给予正确的哺乳指导。Objective To explore the breast feeding of parturients with positive HBsAg. Methods Sixty-eight parturients with positive HBsAg were selected. HBV-M and HBVDNA in their sera and colostrums was detected in postnatal 2～5 days. Results High HBVDNA positive rate in maternal colostrum was detected in HBeAg-and HBVDNA-positive group, while low positive rate in HBeAg and HBVDNA negative group. There was significant difference between both groups(P<0.01). Conclusion The HBeAg and HBVDNA-positive mother is unsuitable to breast feeding.

关 键 词：初乳 肝炎病毒 乙型 HBVDNA 聚合酶链反应 母乳喂养 

分 类 号：R714.251[医药卫生—妇产科学]