3-二茂铁基-2-丁烯酸糖酯的合成及其抗贫血活性  

Synthesis of Glucosyl Esters of 3-ferrocenyl-2-crotonic Acid and Their Antianemic Activity

作　　者：陈勇[1] 韩国防[1] 刘惠英[2] 

机构地区：[1]江苏工业学院化学工程系,江苏常州213016 [2]武汉大学化学系,湖北武汉430072

出　　处：《江苏工业学院学报》2004年第2期8-10,共3页Journal of Jiangsu Polytechnic University

摘　　要：以二茂铁为起始原料,通过相转移催化法和去乙酰作用合成了2种3-二茂铁基-2-丁烯酸糖酯。它们的结构得到IR、EA和MS确证,其中化合物3-二茂铁基-2-丁烯酸四乙酰葡萄糖酯的抗贫血活性得到测试。初步结果表明该化合物具有一定的抗贫血活性,进一步研究有待进行。Two glucosyl esters have been synthesized by means of phase-transfer catalytic method and deacetylation from the starting material ferrocene.Their structures have been confirmed by elementary analysis,IR and MS.Moreover,the antianemic activities of tetraacetyl glucosyl ester of 3-ferrocenyl-2-crotonic acid have been tested.The compound was found to have antianemic activity.The RBC and HB values of the tested anemic rats were increased by 111.5% and 90.1%,respectively after abdomen injection,and therefore,further study is well worth making.

关 键 词：3-二茂铁基-2-丁烯酸 糖苷键化合物 合成 抗贫血活性 

分 类 号：O627.8[理学—有机化学]