内皮素在评价不阻断升主动脉低温室颤对心肌保护作用中的应用  

Evaluation of myocardial preservation by hypothermic ventricular fibrillation without aortic cross—clamping through the levels of ET

作　　者：关晓海[1] 李占清[1] 陈国生[1] 张宇[1] 蒲国华[1] 陈晨[1] 

机构地区：[1]华北煤炭医学院附属医院胸外科,河北唐山063000

出　　处：《华北煤炭医学院学报》2004年第4期413-415,共3页Journal of North China Coal Medical College

摘　　要：①目的　探讨体外循环条件下低温室颤技术对心肌的保护作用。②方法　 1 4只健康成年犬随机分为两组 ,低温停跳组(n =7)与低温室颤组 (n =7) ,分别检测两组手术前、手术 1、2小时和复跳后 1小时 4个时间点血内皮素 (ET)的水平。③结果　室颤组ET水平明显低于停跳组。④结论　通过内皮素水平的变化 ,说明体外循环条件下低温室颤技术是一种安全、有效的心肌保护方式 。Objective To investigate the protective effect of hypothermic ventricular fibrillation on myocardium. Methods Fourteen adult mongrel dogs were randomly divided into two groups: Cold Crystalleid group (Group CC, n=7) and Hypothermic Ventricular Fibrillation group (Group HF, n=7). The levels of ET in blood were tested before operation ,at 1, 2 hours during operation and 1 hour after heart beating. Results In Group HF , the levels of ET were significantly lower than Group CC . Conclusions The technique of hypothermic ventricular fibrillation is a safe and effective strategy to protect the myocardium and superior to the cold crystalleid cardioplegia.

关 键 词：低温室颤 心肌保护 内皮素 

分 类 号：R331.31[医药卫生—人体生理学]