炎症反应在冠心病患者中的作用及临床意义  

Role and clinical significance of inflammatory reaction in patients with coronary heart disease

作　　者：王勇[1] 丁体龙[1] 张玲玲[1] 严家春[1] 俞小忠[1] 石坚[1] 

机构地区：[1]解放军第123医院检验科,安徽蚌埠233015

出　　处：《细胞与分子免疫学杂志》2003年第5期467-468,共2页Chinese Journal of Cellular and Molecular Immunology

摘　　要：目的 :探讨炎症反应与冠心病 (CHD)之间的关系。方法 :10 1例CHD患者分为 3组 ,即稳定型心绞痛 (SAP)组 (19例 )、不稳定型心绞痛 (UAP)组 (33例 )和急性心肌梗死 (AMI)组 (49例 )。分别采用免疫浊度法及血细胞计数仪 ,检测外周血中的C 反应性蛋白 (CRP)水平及白细胞 (WBC)总数。 2 0例AMI死亡患者的心肌组织切片进行病理学检查。结果 :AMI和UAP组血中CRP的水平和WBC总数明显高于对照组 (P <0 .0 1)。病理学检查发现 ,AMI患者心肌中有大量白细胞浸润。结论 :CHD发生、发展有炎症反应的参与 ,检测血中的CRP和WBC可作为监测病情。AIM: To explore the relationship between inflammatory reaction and coronary heart disease (CHD). METHODS: 101 CHD patients were divided into 3 groups, namely 19 cases of stable angina pectoris(SAP), 33 cases of unstable angina pectoris(UAP) and 49 cases of acute myocardial infarction(AMI). Control group C reactive protein(CRP) level and sum of white blood cells(WBC) in peripheral blood were detected by immunoturbidimetry and hemocytometer, respectively. Pathological changes in 20 AMI tissue slice were examined by histochemical staining. RESULTS: The CRP level and sum of WBCs in UAP group were higher than those in SAP group ( P <0.05), but distinctly lower than those in AMI group ( P <0.01). The CRP level and sum of WBCs in AMI group and UAP group were notably higher than those in normal control group ( P <0.01). Histochemical staining showed that there were a great number of leucocyte infiltration in cardiac muscle of AMI patients. CONCLUSION: The inflammatory reaction participats in genesis and development of CHD. CRP level and sum of WBCs may become a useful index for monitoring CHD patient’s condition and prejudging the risk of suffering from CHD.

关 键 词：C-反应性蛋白 白细胞 冠心病 炎症反应 

分 类 号：R541.4[医药卫生—心血管疾病]