银屑病患者负性情绪与神经生长因子受体表达的相关性研究  

The Correlation Between Mood Disorders and Nerve Growth Factor Receptor Expression in Lesions of Psoriasis

作　　者：张锡宝[1] 何荣国[1] 吴志华[2] 

机构地区：[1]广州市皮肤病防治所,510095 [2]广东医学院附属医院皮肤科

出　　处：《中华皮肤科杂志》2004年第3期141-143,共3页Chinese Journal of Dermatology

基　　金：广东省重点科技攻关项目(99050)

摘　　要：目的探讨负性情绪对银屑病患者病程影响的分子病理学基础。方法用免疫组化法(SABC法)检测银屑病患者皮损中神经生长因子(NGF)的2个受体p75和p140trkA表达情况,同时应用焦虑自评量表(SAS)和抑郁自评量表(SDS)对患者进行问卷测评,并进行相关性统计学处理。结果银屑病患者的负性情绪(焦虑与抑郁)程度与2个神经生长因子受体表达呈正相关。结论NGF及其受体是负性情绪影响银屑病患者病情活动程度的重要中介物质。Objective To investigate the molecular mechanism of mood disorders in psoriatic patients.Methods The expression of nerve growth factor receptor p75(NGFR p75)and p140trkA were detected by immunohistochemical technique.The patients' mood was measured with self-rating anxiety scale(SAS)and self-rating depression scale(SDS).Results There is a positive correlation of the expressions of NGFR p75and p140trkA with the patients' mood disorders in psoriatic patients.Conclusion NGF and its receptors are the important substance served as a mediator of the mood disorders affecting psoriatic patients' condition.

关 键 词：银屑病 负性情绪 神经生长因子受体 免疫组化 检测 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]