解毒化淤汤治疗银屑病的临床和实验研究  

A Clinical and Experimental Study on the Use of Decoction of Jie Du Hua Yu Tang in the Treatment of Psoriasis

作　　者：吴胜利[1] 许能[2] 陈建明[1] 李咏梅[2] 马绍尧[2] 

机构地区：[1]上海市崇明县中心医院,202150 [2]上海中医药大学附属龙华医院

出　　处：《中华皮肤科杂志》2004年第3期133-134,共2页Chinese Journal of Dermatology

基　　金：上海区县卫生系统学科带头人培养计划科研项目(9803)

摘　　要：目的研究解毒化淤汤治疗银屑病的临床疗效和作用机制。方法应用解毒化淤汤对50例寻常性银屑病患者进行临床治疗观察,并利用小鼠尾部作银屑病动物模型,以解毒化淤汤灌胃,观察其对小鼠尾部颗粒细胞形成的影响。结果解毒化淤汤治疗银屑病的临床治愈率为42.00%,总有效率为90.00%。动物实验表明解毒化淤汤能明显地增加小鼠尾部鳞片表皮的颗粒层,与对照组比较差异有显著性。结论解毒化淤汤是治疗寻常性银屑病的有效方剂,其作用机制可能与调节自身免疫功能、抑制表皮细胞的增殖有关。Objectives To study the clinical effects and therapeutic mechanisms of the application of Chinese traditional medicine,the Decoction of Jie Du Hua Yu Tang,in the treatment of psoriasis.Meth-ods The clinical effects were observed in50patients with psoriasis vulgaris,to whom the Decoction of Jie Du Hua Yu Tang was given.The mice were used as experimental models whose tail scale epidermis was nat-urally lacking granular layer,similar to psoriatic epidermis.The mice were fed with Jie Du Hua Yu Tang and the effects on the formation of granular layer in their tail scale epidermis were noticed.Results The clinical cure rate was42%and the total response rate was90%with the Jie Du Hua Yu Tang.There was a signifi-cantly strong promoting effect on the formation of granular layer in mouse tail scale epidermis with the use of Jie Du Hua Yu Tang,in comparison with the control group.Conclusions The Decoction of Jie Du Hua Yu Tang is effective for the treatment of psoriasis vulgaris.The decoction could promote the formation of granu-lar layer in mouse tail scale epidermis.The therapeutic mechanism of the decoction may be related to the inhibition of proliferation of epidermal cells.

关 键 词：解毒化淤汤 药物治疗 银屑病 实验 中医药疗法 

分 类 号：R275.9[医药卫生—中西医结合]