利多卡因蛛网膜下腔麻醉致死的动物模型  

Establishment of animal model for the anesthesia accidental death case

作　　者：贠克明[1] 燕炯[1] 郭政[1] 孙俊红[1] 王亚方[1] 薛朝霞[2] 王英元[1] 

机构地区：[1]山西医科大学法医学院,山西太原030001 [2]山西医科大学第一医院麻醉科,山西太原030001

出　　处：《中国法医学杂志》2004年第2期75-77,共3页Chinese Journal of Forensic Medicine

基　　金：山西省自然科学基金资助项目(20031103)

摘　　要：目的 建立利多卡因麻醉致死的动物模型。方法 犬蛛网膜下腔注射利多卡因(37.01mg/kg体重),观察麻醉致死过程的生命体征变化及死后各器官的病理改变特点。结果 实验组犬心电、血压和呼吸消失的平均时间分别为23.8min(7-42min)、16.4min(7-35min)和18.6min(10～47min)。各器官病理改变均呈急死征象。结论 所建模型实验动物的表现和生命体征变化符合蛛网膜下腔麻醉致死的生前表现,可应用于利多卡因麻醉意外致死案件法医学鉴定的实验研究。Objective To establish animal model of the anesthesia accidental death case with dog. Methods To observe the vital signs and pathologic alteration of dogs after a dose of Lidocaine (37. 01 mg/ kg) by subarachnoid space injection. Results The blood pressure, respiration and electro cardiac of the dogs disappeared within 23. 8 min (7-42min ) , 16. 4 min (7-35 min) and 18. 6 min (10-47 min) respectively after the injection. The dogs showed the pathology of sudden death. Conclusion The changes of phe-notype and vital signs in this model were similar to those died of the subarachnoid anaesthesia with lidocaine. This study provides an animal model for the identification study of subarachnoid anaesthesia death.

关 键 词：利多卡因 蛛网膜下腔麻醉 动物模型 死亡 病理特点 法医学鉴定 

分 类 号：D919[医药卫生—法医学]