哌仑西平脂质体的研制及评价  

Preparation and Evaluation of Pirenzepine Liposome

作　　者：戴淑真[1] 曾骏文[1] 王子亮[2] 吴昌凡[1] 

机构地区：[1]中山大学眼科中心,广东广州510060 [2]中山大学附属第一医院放射介入科,广东广州510060

出　　处：《中山大学学报（医学科学版）》2004年第3期217-220,240,共5页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：美国CMB基金资助项目(98-677);广州市科技计划项目(2002z-0142)

摘　　要：【目的】 制备稳定性好?包封率高?缓释性能优的哌仑西平脂质体?【方法】采用均匀设计等方法筛选制备哌仑西平脂质体的处方和工艺,并对其形态?粒径?包封率?加速实验结果及体外释放规律进行考察?【结果】 制得的哌仑西平脂质体为单层脂质体,平均粒径为480 nm,包封率为77.24%±9.83%,其稳定性好,缓释效果优于哌仑西平磷酸缓冲液?【结论】 哌仑西平脂质体达到设计要求?Objective To prepare pirenzepine liposome with good stability,high entrapment efficien-cy and sustained-release effect. Methods The uniform design method was used to optimize the recipe and technology for preparing the pirenzepine liposome. Then the shape, particle size, entrapment efficien-cy, the results of accelerating experiments and releasing law in vitro of the liposome was investigated. Results The liposome is mono-layer vesicle; its mean particle size is 480 nm and average entrap-ment efficiency of the prepared liposome is 77.24%±9.83%. The stability is good and the liposome has the better sustained-release effect than pirenzepine phosphoric acid buffer solution. Conclusions Pirenzepine liposome is consistent with the design supposition.

关 键 词：哌仑西平 脂质体 制备工艺 眼科药物 药物载体 

分 类 号：TQ460.6[化学工程—制药化工]