卵巢子宫内膜异位症微血管密度及血管内皮生长因子表达  

Microvessel Density and Expression of Vascular Endothelial Growth Factor in Ovarian Endometriosis

作　　者：王宁宁[1] 庄广伦[1] 黄建昭[1] 姚书忠[1] 周慕珩[2] 董愉[2] 

机构地区：[1]中山大学附属第一医院妇产科,广东广州510080 [2]中山大学病理学教研室,广东广州510080

出　　处：《中山大学学报（医学科学版）》2004年第3期264-267,共4页Journal of Sun Yat-Sen University:Medical Sciences

摘　　要：【目的】 探讨子宫内膜异位症血管内皮生长因子(VEGF)的表达,微血管生成及其与临床病理发生的关系? 【方法】 采用S-P免疫组化染色法检测50例卵巢子宫内膜异位症,21例子宫肌瘤在位内膜和10例子宫腺肌症在位内膜中VEGF的表达及微血管密度(MVD)?【结果】 卵巢子宫内膜异位症的VEGF表达阳性率上皮为13.69±4.32?间质为9.24±6.55;MVD(160±53) /mm2,显著高于子宫肌瘤?子宫腺肌症的在位子宫内膜的VEGF阳性表达率与MVD值(P< 0.05),且VEGF与M VD值呈正相关(P< 0.05)? 子宫内膜异位症组按r-AFS分期,15 例Ⅰ-Ⅱ 期,35例Ⅲ-Ⅳ期,二组在VEGF的阳性表达率?MVD无显著性差异(P >0.05),与临床分期不相关?【结论】 异位内膜组织VEGF的过度表达可能参与异位内膜的血管生成过程,为抗血管生成治疗提供了理论依据?Objective To investigate the expression of vascular endothelial growth factor(VEGF) and angiogenesis in endometriosis and it relationship with clinical pathogene-sis. Methods S-P immunohistochemical method was used to detect VEGF expression and MVD in Lesions in 50 cases of ovarian endometrioma ,endometrium in 21 cases of myoma and 10 cas-es of adenomyosis. Results The positive rate of VEGF in ovarian endometrioma was 13.69±4.32 in epithelium, 9.24±6.55 in stroma MVD (160±53/mm2 ) was higher in endometrioma than in eutopic endometrium of myoma and adenomyosis. The difference was significant(P< 0.05) .There was positive relation between MVD and VEGF positive rate.According to (r-AFS) stage,there were no significance in positive rate of VEGF and MVD between 15 cases of Stage Ⅰ-Ⅱ and 35 cases of Stage Ⅲ -Ⅳ groups (P >0.05) . No correlation was found in clinical stage of endometriosis. Conclusion Overexpression VEGF of endometriotic tissue may partici-pate in angiogenesis process. It could be a theoretical basis for the treatment of endometriosis by an-ti-angiogenesis.

关 键 词：子宫内膜异位症 微血管密度 血管内皮生长因子 免疫组织化学 血管生成 

分 类 号：R711.71[医药卫生—妇产科学]