片剂聚合物水性包衣工艺的优化研究  

Optimization of aqueous polymeric coating tablets technique

作　　者：刘秀霞[1] 石威武[1] 孙海胜[1] 金冲[1] 徐土根[1] 欧阳林[1] 

机构地区：[1]江苏扬子江药业集团公司,江苏泰州225321

出　　处：《中国药学杂志》2004年第5期382-384,共3页Chinese Pharmaceutical Journal

摘　　要：目的 优化水溶性溶剂薄膜包衣工艺。方法 通过调整进气流量、锅体转速等工艺参数优化包衣工艺。结果 优化工艺各参数值分别是:进气流量在[(320±10)％]m3·h-1,根据包衣状态锅体转速值为3-10 r·min-1,片芯温度:40-42℃,进气温度、喷射速率的选择取决于包衣液所要求的维持稳定的片剂芯床温度。结论 表明了水溶性溶剂薄膜包衣工艺在几个被动变量(Tc和H)与独立变量(Tv,Fv和Rs)之间存在重要的关系。OBJECTIVE: To optimize the aqueous film coating technique. METHODS: The film coating technique of tablets was optimized by selecting suited technique parameters. RESULTS: The optimum technique parameters were shown as follows: entering air flux [(320 ± 10)%] m3 &middot h-1, rotate speed of coating machine 3 - 10 r&middotmin-1, and the temperature of tablet cores in coating machine 40 - 42 °C. But entering air temperature and spraying rate depended on the temperature of stable tablet score. CONCLUSION: The investigation results suggested an important relations between passive variables and independent variables on aqueous film coating technique.

关 键 词：片剂 聚合物 工艺优化 水溶性溶剂 薄膜包表 

分 类 号：R944.4[医药卫生—药剂学]