精氨酸布洛芬滴眼液的制备及质量控制  

Preparation and quality control of arginine-ibuprofen eye drops

作　　者：李仲昆 靳梅 尹为民[2] 王珩 王崇静 李冰 

机构地区：[1]昆明市延安医院,云南昆明650051 [2]云南省第一人民医院,云南昆明650032

出　　处：《中国药学杂志》2004年第5期362-363,共2页Chinese Pharmaceutical Journal

摘　　要：目的 研制精氨酸布洛芬滴眼液以适应患者需求。方法 按处方配制成布洛芬浓度为3 mg·mL-1的精氨酸布洛芬滴眼液,采用紫外分光光度法测定其含量,建立其质量控制标准。结果 制备工艺可行,处方成分在272 nm处有最大吸收,其它成分在此波长处无吸收,质量控制可靠。结论 该剂型可以应用于临床。OBJECTIVE: To prepare arginine-ibuprofen eye drops to meet the need of patients. METHODS: Arginine-ibuprofen eye drops was prepared. The concentration of ibuprofen was 3 mg&middotmL-1. UV spectrophotometry was used to determine the content of ibuprofen. Quality control standard was established. RESULTS: The process was practicable. Ibuprofen had maximum absorption at 272 nm. The other components had not absorption at this wavelength. The quality standard may be used to control the quality of this product. CONCLUSION: It may be used in clinical.

关 键 词：精氨酸布洛芬滴眼液 制备 质量控制 紫外分光光度法 含量测定 

分 类 号：R944[医药卫生—药剂学]