葛根黄酮滴丸兔体内药动学  

Pharmacokinetics of Gegen Huangtong dripping pills in rabbits

作　　者：郭建平 成国祥[2] 孙其荣[3] 周全[3] 姚康德[2] 

机构地区：[1]解放军二六三医院,北京100149 [2]天津大学,天津300072 [3]第二军医大学药学院,上海200433

出　　处：《中国药学杂志》2004年第5期364-365,共2页Chinese Pharmaceutical Journal

基　　金：北京军区医药卫生科研课题重点课题

摘　　要：目的 观察葛根黄酮滴丸在家兔体内的释放过程,同时进行药动学研究。方法 12只实验兔随机分为两组,分别服用葛根黄酮滴丸和愈风宁心片,均含葛根黄酮100 mg,用HPLC检测,Mcp86软件估算两制剂的生物利用度。结果 滴丸和片剂主要药动学参数分别为:AUC0-24599.7,294.6μg·h·mL-1;tmax0.81,1.70 h;t1/2Ka0.62,0.43 h;Cmax0.56,0.19μg·mL-1。葛根黄酮滴丸和愈风宁心片在家免体内的药-时过程为二室模型。绝对生物利用度F=203.5％。结论 AUC0-24,Cmax,tmax经配对t检验均有显著性差异,提示葛根黄酮滴丸可提高生物利用度、快速释药的特点。OBJECTIVE: To investigate the releasing process and the pharmacokinetics of Gegen Huangtong dripping pills in rabbits. METHODS: Twelve rabbits were divided into two equal groups. Single oral administration of isoflavones (100 mg&middotkg-1)as Gegen Huangtong dripping pills or Yufeng Ningxin tablets was taken. MCP86 was used to calculate the pharmacokinetic parameters and the absolute bioavailability. RESULTS: The main pharmacokinetic parameters of the dripping pills and the tablets were as follows: AUC0-24 599.7 and 294.6 μg&middoth&middot mL-1; tmax 0. 81 and 1.70 h; t1/2Ka 0.62 and 0.43 h; cmax 0.56 and 0.19 μg&middotmL-1, respectively. The plasma concentration -time course of Gegen Huangtong dripping pills and Yufeng Ningxin tablets in rabbits was best fitted to an open two compartment model. The absolute bioavailability of the dripping pills was 203.5%. There were significant differences for AUC0-24, cmax and tmax between the two groups. CONCLUSION: Gegen Huangtong dripping pills has better bioavaiability and can release drugs quickly. The study shows the rationality of preparing dripping pills and provide the basis for its quality evalualion in human body.

关 键 词：葛根黄酮滴丸 兔 药动学 愈风宁心片 反相高效液相色谱法 

分 类 号：R969.1[医药卫生—药理学]