Effects of bile reflux and intragastric microflora changes on lesions of remnant gastric mucosa after gastric operation  

作　　者：ChaoZhang Zhan-KuiLiu Pei-WuYu 

机构地区：[1]DepartmentofGeneralSurgery,SouthwestHospital,ThirdMilitaryMedicalUniversity,GaotanYan,Chongqing400038,China

出　　处：《World Journal of Gastroenterology》2004年第10期1537-1539,共3页世界胃肠病学杂志（英文版）

摘　　要：AIM: To investigate the effects of bile reflux and intragastric microflora changes on lesions of remnant gastric mucosa after gastric operation.METHODS: Concenration of bile acid and total bacterial counts (TBC) in gastric juice were measured in 49 patients with peptic ulcer before and after gastrectomy. One year after the operation, sample of gastric mucosa taken from all the patients were used for histological examination.RESULTS: The concentration of gastric bile acid was significantly increased in group B-I, or B-II and SV+A than that in group HSV (P<0.05-0.01). The abnormal histological changes in the remnant gastric mucosa were more common in the first 2 groups than in the last group.CONCLUSION: The type of gastrtectomy can affect bile reflux. The abnormal histological changes in the remnant gastric mucosa are closely related to the elevation of bile acid concentration and increase of TBC in gastric juice. HSV can effectively prevent bile reflux and keep the gastric physiological functions stable.AIM: To investigate the effects of bile reflux and intragastric microflora changes on lesions of remnant gastric mucosa after gastric operation. METHODS: Concenration of bile acid and total bacterial counts (TBC) in gastric juice were measured in 49 patients with peptic ulcer before and after gastrectomy.One year after the operation,sample of gastric mucosa taken from all the patients were used for histological examination. RESULTS: The concentration of gastric bile acid was significantly increased in group B-Ⅰ,or B-Ⅱ and SV+A than that in group HSV (P<0.05-0.01).The abnormal histological changes in the remnant gastric mucosa were more common in the first 2 groups than in the last group. CONCLUSION: The type of gastrtectomy can affect bile reflux.The abnormal histological changes in the remnant gastric mucosa are closely related to the elevation of bile acid concentration and increase of TBC in gastric juice.HSV can effectively prevent bile reflux and keep the gastric physiological functions stable.

关 键 词：胆汁返流 胃手术 残胃粘膜 胃内微生物 组织病理学 

分 类 号：R656.61[医药卫生—外科学]