四物汤对小鼠脾细胞分泌IL-3和IL-2的促进作用  

Siwutang enhancing production of IL-3 and IL-2 by splenocytes in Con A-primed mice

作　　者：曹蔚蔚[1] 郑钦岳[2] 杨延莉[1] 

机构地区：[1]解放军第411医院药剂科,上海200081 [2]第二军医大学药学院药理学教研室,上海200433

出　　处：《第二军医大学学报》2004年第5期558-559,共2页Academic Journal of Second Military Medical University

基　　金：国家自然科学基金(39070966)

摘　　要：目的:研究四物汤对小鼠脾细胞分泌IL-3和IL-2的促进作用。方法:用3H-TdR掺入法和斑点杂交法,考察四物汤对刀豆球蛋白A(Con A)诱导的小鼠脾淋巴细胞分泌IL-3和IL-2的影响。结果:四物汤可显著促进Con A诱导的脾淋巴细胞分泌IL-3和IL-2(P<0.01,P<0.05),促进淋巴细胞中IL-3 mRNA的表达。结论:四物汤能增强小鼠的造血功能。Objective:To investigate the effect of Siwutang on promoting hematopoietic function of mouse splenocytes. Methods:Effect of Siwutang on concanavalin A (Con A)-primed mice splenocytes production of IL-3 and IL-2 was studied by 3H-TdR incorporation and dot blot hybridization. Results: Siwutang significantly enhanced Con A-primed mice splenocytes production of IL-3 and IL-2(P<0. 01, P<0. 05) and it also promoted the IL-3 mRNA expression in lymphocytes. Conclusion :Siwutang can augment the hematopoietic function in mice.

关 键 词：四物汤 小鼠 脾细胞 分泌 IL-3 IL-2 促进作用 中药 

分 类 号：R285.5[医药卫生—中药学]