洛索洛芬钠在健康中国人体内的药代动力学研究  

Pharmacokinetic study on loxoprofen sodium in healthy Chinese volunteers

作　　者：缪海均[1] 邓渝林[1] 樊成辉[1] 刘皋林[1] 

机构地区：[1]第二军医大学长征医院药学部,上海200003

出　　处：《第二军医大学学报》2004年第5期568-569,共2页Academic Journal of Second Military Medical University

摘　　要：目的:研究洛索洛芬钠在健康中国人体内的药代动力学.方法:选取18名健康志愿者单剂量口服60 mg洛索洛芬钠片,采用高效液相层析法测定血浆中洛索洛芬钠药物浓度,计算药代动力学参数.结果:主要药代动力学参数t1/2、cmax、tmax、AUC0～8 h分别为(121.4±23.4)min、(3.69±0.77)μg/ml、(30.8±7.1)mtn、(397.4±68.4)μg·min/ml.结论:本品口服吸收快,消除半衰期短.洛索洛芬钠的体内过程符合二室开放模型.Objective: To study the pharmacokinetics of loxoprofen sodium in healthy Chinese volunteers. Methods: Eighteen volunteers were chosen for a single dose of 60 mg loxoprofen sodium tablet. Drug concentrations in plasma were measured by HPLC method and the pharmacokinetic parameters were calculated. Results: t1/2 , cmax, tmax and AUC were (121. 4±23. 4) min,(3. 69 ± 0. 77) μg/ml, (30. 8 ± 7. 1) min, and (397. 4±68. 4) μg · min/ml .respectively. Conclusion; Loxoprofen has rapid absorption and short elimination rate after oral administration. Plasma concentration-time curve of loxoprofen sodium conforms to a two-compartment open pharmacokinetic model.

关 键 词：洛索洛芬钠 体内 药代动力学 高压液相 

分 类 号：R971.1[医药卫生—药品]