三七总皂苷对痴呆模型大鼠大脑皮质内神经递质含量的影响  

Effects of Panax notoginseng saponins on the concentrations of neurotransmitters in brain of Alzheimer's disease model mouse

作　　者：郭长杰[1] 伍杰雄[2] 李若馨[3] 

机构地区：[1]北京大学深圳医院药剂科,深圳518036 [2]中山大学广州北校区医务科,广州510080 [3]深圳市儿童医院儿研所,深圳518036

出　　处：《中国临床药学杂志》2004年第3期150-152,共3页Chinese Journal of Clinical Pharmacy

摘　　要：目的 :观察三七总皂苷 (PNS)对痴呆模型大鼠大脑皮质内去甲肾上腺素 (NE)、多巴胺 (DA)和 5 羟色胺 (5 HT)含量的影响。方法 :以鹅膏蕈氨酸注入大鼠Meynert基底核建立痴呆模型。 30只实验大鼠随机分为NS组 ;5 0mg·kg-1PNS组和 10 0mg·kg-1PNS组。采用高效液相电化学法测定NE ,DA和 5 HT含量。结果 :10 0mg·kg-1PNS组中 3种递质的含量均高于 5 0mg·kg-1PNS组 (P <0 0 5 ) ,而 5 0mg·kg-1PNS组又高于NS组 (P <0 0 5 )。结论 :PNS能够提高痴呆模型大鼠大脑皮质内NE ,DA和5AIM:To observe the effects of Panax notoginseng saponins (PNS) on concentrations of norepinephrine (NE), dopamine (DA) and serotonin (5-HT) in brain of model mouse. METHODS: Ibotenic acid was injected into basalis magnocellularis to develop the model. Thirty mice were divided into 3 groups:NS group, 50 mg·kg -1PNS group,100 mg·kg -1PNS group. Concentrations of NE, DA and 5-HT were detected by HPLC with electrochemical detectionmethod. RESULTS: Concentrations of NE, DA and 5-HT in 100 mg·kg -1 group were higher than those in 50 mg·kg -1 group. Concentrations of NE, DA and 5-HT in 50 mg·kg -1 group were higher than those in NS group. CONCLUSION: PNS can increase the concentrations of NE, DA and 5-HT in mouse brain.

关 键 词：三七总皂苷 老年痴呆 动物模型 大鼠 大脑皮质 神经递质 多巴胺 5-羟色胺 

分 类 号：R285[医药卫生—中药学]