HPLC法测定吗氯贝胺片含量  

Determination of Moclobemide by HPLC

作　　者：王守箐 徐斌 

机构地区：[1]鲁南制药股份有限公司,临沂276003

出　　处：《齐鲁药事》2004年第2期20-21,共2页qilu pharmaceutical affairs

摘　　要：目的　建立了一种测定吗氯贝胺的HPLC新方法。方法　在室温下以甲醇∶水(30∶70 )为流动相,检测波长为2 4 0nm,流速为 1 0ml·min-1。结果　吗氯贝胺在 2 5～ 80 μg·ml-1范围内呈良好线性,最低检测限为 3 0ng,回收率为 98 9～10 0 2 %。结论　本法简便,准确,重现性好。Objective To establish a HPLC method for the determination of Moclobemide. Methods Ethanol and water (30∶70) as mobile phase , detected at a wavelength of 240nm, flow rate was 1.0ml·min -1. Results Good linearity was showed in the concentration of 2.5～80μg·ml -1, detect limit was 3.0ng, the recovery was 98.9～100.2%. Conlusion The method was simple, accurate and repeatable. This method can be used as a quantity control method of determination of Moclobemide.

关 键 词：HPLC法 吗氯贝胺 含量测定 质量控制 抗抑郁药 

分 类 号：R927.2[医药卫生—药学] R971.43