早期皮质激素干预对哮喘儿童肺功能的影响  

Affect of Early Corticosteroids Interference on Lung Function of Asthma Children

作　　者：张少明[1] 顾洪亮[1] 钱耀琴[1] 王平[1] 戴星[1] 

机构地区：[1]上海第二医科大学附属第九人民医院儿童哮喘防治中心,上海200011

出　　处：《华夏医学》2004年第2期144-146,共3页Acta Medicinae Sinica

摘　　要：目的 :通过对不同病程的哮喘儿童发作期和缓解期的肺功能分析 ,探讨早期皮质激素干预在哮喘治疗中的作用。方法 :将 2 17例未接受过皮质激素规范治疗的哮喘儿童 ,根据在我院初诊前的病程和初诊时的症状分为 4组。A组4 9例为病程≤ 2年、初诊时处于发作期 ,B组 2 5例为病程≤ 2年、初诊时处于缓解期 ,C组 98例为病程 >2年、初诊时处于发作期 ,D组 4 5例为病程 >2年、初诊时处于缓解期 ,分别在治疗前及治疗后半年测定肺功能指标 FVC、FEV1 、PEF和 MEF值。结果 :1A组和 C组患者在初诊时肺功能指标 FVC、FEV1 、PEF和 MEF值均低于预计值 80 % ,二组间无显著性差异。 2 B组和 D组患者在初诊时肺功能指标 FVC值均大于预计值的 80 % ,而 FEV1 、PEF和 MEF值均小于预计值的 80 % ,且 D组的 MEF值明显低于 B组 ,二者有显著性差异。 34组患者用皮质激素干粉剂吸入治疗后半年肺功能指标均较治疗前有显著改善 ,治疗前病程≤ 2年的患儿经皮质激素吸入治疗后肺功能改善比病程 >2年的患儿明显 ,尤其是代表小气道功能的 PEF和 MEF有显著性差异。结论 :对哮喘儿童早期规范使用皮质激素吸入治疗有利于其肺功能的改善。Objective:To e xplore the action of early corticosteriods interference on lung function of asth ma children.Methods:217 cases of asthma were investigated.The average age and body weight were 8.34±2.46g and 29 37±8 74kg,respectively.Four groups were d esigned in order to determine the effect.Group A consisted of 49 cases,disease c ourse was less or equal to tow years and on attack period.Group B consisted of 2 5 cases,the same disease course as group A and on relief period.Group C consist ed of 98 cases,disease course was longer than tow years and on attack period.Gro up D consisted of 45 cases,the same disease course as group C and on relief peri od.The indies of lung function:FVC,FEV 1,PEF and MEF were measured before and a fter a half year's treatment.Results:①The values of FVC,FEV 1,PEF and MEF in group A and C were less than 80% of the standard value.②The values of FVC in group B an d D were larger than 80% of the standard value,but FEV 1,PEF and MEF were less th an 80% of the standard value.③The indies of lung function improved remarkably a fter the inhalation treatment using dry powder of corticosteriods in patients wh ose disease course was less or equal to tow years as compared with those whose d isease course was longer than tow years.The values of PEF and MEF showed the sig nificant difference among them.Conclusion:The early,formal corticosteriods inhalation benifits to improve lung function of asthma children.

关 键 词：儿童哮喘 皮质激素 肺功能 

分 类 号：R725.6[医药卫生—儿科] R562.25[医药卫生—临床医学]